IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-11844-z.html
   My bibliography  Save this article

An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation

Author

Listed:
  • Sandra Van Puyvelde

    (Institute of Tropical Medicine
    Wellcome Genome Campus, Hinxton
    University of Antwerp)

  • Derek Pickard

    (Wellcome Genome Campus, Hinxton
    Addenbrooke’s Hospital, University of Cambridge)

  • Koen Vandelannoote

    (Institute of Tropical Medicine)

  • Eva Heinz

    (Wellcome Genome Campus, Hinxton
    Liverpool School of Tropical Medicine)

  • Barbara Barbé

    (Institute of Tropical Medicine)

  • Tessa de Block

    (Institute of Tropical Medicine)

  • Simon Clare

    (Wellcome Genome Campus, Hinxton)

  • Eve L. Coomber

    (Wellcome Genome Campus, Hinxton)

  • Katherine Harcourt

    (Wellcome Genome Campus, Hinxton)

  • Sushmita Sridhar

    (Wellcome Genome Campus, Hinxton
    Addenbrooke’s Hospital, University of Cambridge)

  • Emily A. Lees

    (Wellcome Genome Campus, Hinxton
    Addenbrooke’s Hospital, University of Cambridge)

  • Nicole E. Wheeler

    (Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton)

  • Elizabeth J. Klemm

    (Wellcome Genome Campus, Hinxton)

  • Laura Kuijpers

    (Institute of Tropical Medicine
    KU Leuven, Herestraat 49—box 1030)

  • Lisette Mbuyi Kalonji

    (National Institute for Biomedical Research
    University Hospital of Kinshasa)

  • Marie-France Phoba

    (National Institute for Biomedical Research
    University Hospital of Kinshasa)

  • Dadi Falay

    (University Hospital of Kisangani)

  • Dauly Ngbonda

    (University Hospital of Kisangani)

  • Octavie Lunguya

    (National Institute for Biomedical Research
    University Hospital of Kinshasa)

  • Jan Jacobs

    (Institute of Tropical Medicine
    KU Leuven, Herestraat 49—box 1030)

  • Gordon Dougan

    (Wellcome Genome Campus, Hinxton
    Addenbrooke’s Hospital, University of Cambridge)

  • Stijn Deborggraeve

    (Institute of Tropical Medicine)

Abstract

Bloodstream infections by Salmonella enterica serovar Typhimurium constitute a major health burden in sub-Saharan Africa (SSA). These invasive non-typhoidal (iNTS) infections are dominated by isolates of the antibiotic resistance-associated sequence type (ST) 313. Here, we report emergence of ST313 sublineage II.1 in the Democratic Republic of the Congo. Sublineage II.1 exhibits extensive drug resistance, involving a combination of multidrug resistance, extended spectrum β-lactamase production and azithromycin resistance. ST313 lineage II.1 isolates harbour an IncHI2 plasmid we name pSTm-ST313-II.1, with one isolate also exhibiting decreased ciprofloxacin susceptibility. Whole genome sequencing reveals that ST313 II.1 isolates have accumulated genetic signatures potentially associated with altered pathogenicity and host adaptation, related to changes observed in biofilm formation and metabolic capacity. Sublineage II.1 emerged at the beginning of the 21st century and is involved in on-going outbreaks. Our data provide evidence of further evolution within the ST313 clade associated with iNTS in SSA.

Suggested Citation

  • Sandra Van Puyvelde & Derek Pickard & Koen Vandelannoote & Eva Heinz & Barbara Barbé & Tessa de Block & Simon Clare & Eve L. Coomber & Katherine Harcourt & Sushmita Sridhar & Emily A. Lees & Nicole E., 2019. "An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11844-z
    DOI: 10.1038/s41467-019-11844-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-11844-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-11844-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tuan-Anh Tran & Sushmita Sridhar & Stephen T. Reece & Octavie Lunguya & Jan Jacobs & Sandra Puyvelde & Florian Marks & Gordon Dougan & Nicholas R. Thomson & Binh T. Nguyen & Pham The Bao & Stephen Bak, 2024. "Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in isolates of Salmonella Typhimurium," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Ying Xiang & Kunpeng Zhu & Kaiyuan Min & Yaowen Zhang & Jiangfeng Liu & Kangkang Liu & Yiran Han & Xinge Li & Xinying Du & Xin Wang & Ying Huang & Xinping Li & Yuqian Peng & Chaojie Yang & Hongbo Liu , 2024. "Characterization of a Salmonella enterica serovar Typhimurium lineage with rough colony morphology and multidrug resistance," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Wim L. Cuypers & Pieter Meysman & François-Xavier Weill & Rene S. Hendriksen & Getenet Beyene & John Wain & Satheesh Nair & Marie A. Chattaway & Blanca M. Perez-Sepulveda & Pieter-Jan Ceyssens & Tessa, 2023. "A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11844-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.