Author
Listed:
- Khaled Ghandour
(University of Toyama
Japan Science and Technology Agency (JST)
JST)
- Noriaki Ohkawa
(University of Toyama
Japan Science and Technology Agency (JST)
JST)
- Chi Chung Alan Fung
(Japan Science and Technology Agency (JST)
RIKEN Center for Brain Science
Okinawa Institute of Science and Technology)
- Hirotaka Asai
(University of Toyama
Japan Science and Technology Agency (JST))
- Yoshito Saitoh
(University of Toyama
Japan Science and Technology Agency (JST)
JST)
- Takashi Takekawa
(Japan Science and Technology Agency (JST)
Kogakuin University)
- Reiko Okubo-Suzuki
(University of Toyama
Japan Science and Technology Agency (JST))
- Shingo Soya
(University of Tsukuba)
- Hirofumi Nishizono
(Japan Science and Technology Agency (JST)
University of Toyama)
- Mina Matsuo
(University of Toyama)
- Makoto Osanai
(Tohoku University Graduate School of Medicine
Tohoku University)
- Masaaki Sato
(RIKEN Center for Brain Science
Saitama University
Saitama University)
- Masamichi Ohkura
(Saitama University
Saitama University
Kyushu University of Health and Welfare)
- Junichi Nakai
(Saitama University
Saitama University)
- Yasunori Hayashi
(RIKEN Center for Brain Science
Saitama University
Kyoto University)
- Takeshi Sakurai
(University of Tsukuba)
- Takashi Kitamura
(University of Texas Southwestern Medical Center
University of Texas Southwestern Medical Center)
- Tomoki Fukai
(Japan Science and Technology Agency (JST)
RIKEN Center for Brain Science
Okinawa Institute of Science and Technology)
- Kaoru Inokuchi
(University of Toyama
Japan Science and Technology Agency (JST))
Abstract
The brain stores and recalls memories through a set of neurons, termed engram cells. However, it is unclear how these cells are organized to constitute a corresponding memory trace. We established a unique imaging system that combines Ca2+ imaging and engram identification to extract the characteristics of engram activity by visualizing and discriminating between engram and non-engram cells. Here, we show that engram cells detected in the hippocampus display higher repetitive activity than non-engram cells during novel context learning. The total activity pattern of the engram cells during learning is stable across post-learning memory processing. Within a single engram population, we detected several sub-ensembles composed of neurons collectively activated during learning. Some sub-ensembles preferentially reappear during post-learning sleep, and these replayed sub-ensembles are more likely to be reactivated during retrieval. These results indicate that sub-ensembles represent distinct pieces of information, which are then orchestrated to constitute an entire memory.
Suggested Citation
Khaled Ghandour & Noriaki Ohkawa & Chi Chung Alan Fung & Hirotaka Asai & Yoshito Saitoh & Takashi Takekawa & Reiko Okubo-Suzuki & Shingo Soya & Hirofumi Nishizono & Mina Matsuo & Makoto Osanai & Masaa, 2019.
"Orchestrated ensemble activities constitute a hippocampal memory engram,"
Nature Communications, Nature, vol. 10(1), pages 1-14, December.
Handle:
RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10683-2
DOI: 10.1038/s41467-019-10683-2
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Citations
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Cited by:
- Masakazu Agetsuma & Issei Sato & Yasuhiro R. Tanaka & Luis Carrillo-Reid & Atsushi Kasai & Atsushi Noritake & Yoshiyuki Arai & Miki Yoshitomo & Takashi Inagaki & Hiroshi Yukawa & Hitoshi Hashimoto & J, 2023.
"Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation,"
Nature Communications, Nature, vol. 14(1), pages 1-22, December.
- Heather C. Ratigan & Seetha Krishnan & Shai Smith & Mark E. J. Sheffield, 2023.
"A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination,"
Nature Communications, Nature, vol. 14(1), pages 1-17, December.
- Kareem Abdou & Masanori Nomoto & Mohamed H. Aly & Ahmed Z. Ibrahim & Kiriko Choko & Reiko Okubo-Suzuki & Shin-ichi Muramatsu & Kaoru Inokuchi, 2024.
"Prefrontal coding of learned and inferred knowledge during REM and NREM sleep,"
Nature Communications, Nature, vol. 15(1), pages 1-15, December.
- Masanori Nomoto & Emi Murayama & Shuntaro Ohno & Reiko Okubo-Suzuki & Shin-ichi Muramatsu & Kaoru Inokuchi, 2022.
"Hippocampus as a sorter and reverberatory integrator of sensory inputs,"
Nature Communications, Nature, vol. 13(1), pages 1-15, December.
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