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The hydrolase LpqI primes mycobacterial peptidoglycan recycling

Author

Listed:
  • Patrick J. Moynihan

    (University of Birmingham)

  • Ian T. Cadby

    (University of Birmingham)

  • Natacha Veerapen

    (University of Birmingham)

  • Monika Jankute

    (University of Birmingham)

  • Marialuisa Crosatti

    (University of Leicester)

  • Galina V. Mukamolova

    (University of Leicester)

  • Andrew L. Lovering

    (University of Birmingham)

  • Gurdyal S. Besra

    (University of Birmingham)

Abstract

Growth and division by most bacteria requires remodelling and cleavage of their cell wall. A byproduct of this process is the generation of free peptidoglycan (PG) fragments known as muropeptides, which are recycled in many model organisms. Bacteria and hosts can harness the unique nature of muropeptides as a signal for cell wall damage and infection, respectively. Despite this critical role for muropeptides, it has long been thought that pathogenic mycobacteria such as Mycobacterium tuberculosis do not recycle their PG. Herein we show that M. tuberculosis and Mycobacterium bovis BCG are able to recycle components of their PG. We demonstrate that the core mycobacterial gene lpqI, encodes an authentic NagZ β-N-acetylglucosaminidase and that it is essential for PG-derived amino sugar recycling via an unusual pathway. Together these data provide a critical first step in understanding how mycobacteria recycle their peptidoglycan.

Suggested Citation

  • Patrick J. Moynihan & Ian T. Cadby & Natacha Veerapen & Monika Jankute & Marialuisa Crosatti & Galina V. Mukamolova & Andrew L. Lovering & Gurdyal S. Besra, 2019. "The hydrolase LpqI primes mycobacterial peptidoglycan recycling," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10586-2
    DOI: 10.1038/s41467-019-10586-2
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    Cited by:

    1. Omar Al-Jourani & Samuel T. Benedict & Jennifer Ross & Abigail J. Layton & Phillip Peet & Victoria M. Marando & Nicholas P. Bailey & Tiaan Heunis & Joseph Manion & Francesca Mensitieri & Aaron Frankli, 2023. "Identification of d-arabinan-degrading enzymes in mycobacteria," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Aaron Franklin & Vivian C. Salgueiro & Abigail J. Layton & Rudi Sullivan & Todd Mize & Lucía Vázquez-Iniesta & Samuel T. Benedict & Sudagar S. Gurcha & Itxaso Anso & Gurdyal S. Besra & Manuel Banzhaf , 2024. "The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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