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Vibrio sp. dhg as a platform for the biorefinery of brown macroalgae

Author

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  • Hyun Gyu Lim

    (Pohang University of Science and Technology)

  • Dong Hun Kwak

    (Pohang University of Science and Technology)

  • Sungwoo Park

    (Seoul National University)

  • Sunghwa Woo

    (Pohang University of Science and Technology)

  • Jae-Seong Yang

    (Pohang University of Science and Technology)

  • Chae Won Kang

    (Pohang University of Science and Technology)

  • Beomhee Kim

    (Seoul National University)

  • Myung Hyun Noh

    (Pohang University of Science and Technology)

  • Sang Woo Seo

    (Seoul National University)

  • Gyoo Yeol Jung

    (Pohang University of Science and Technology
    Pohang University of Science and Technology)

Abstract

Although brown macroalgae holds potential as an alternative feedstock, its utilization by conventional microbial platforms has been limited due to the inability to metabolize one of the principal sugars, alginate. Here, we isolate Vibrio sp. dhg, a fast-growing bacterium that can efficiently assimilate alginate. Based on systematic characterization of the genomic information of Vibrio sp. dhg, we establish a genetic toolbox for its engineering. We also demonstrate its ability to rapidly produce ethanol, 2,3-butanediol, and lycopene from brown macroalgae sugar mixture with high productivities and yields. Collectively, Vibrio sp. dhg can be used as a platform for the efficient conversion of brown macroalgae sugars into diverse value-added biochemicals.

Suggested Citation

  • Hyun Gyu Lim & Dong Hun Kwak & Sungwoo Park & Sunghwa Woo & Jae-Seong Yang & Chae Won Kang & Beomhee Kim & Myung Hyun Noh & Sang Woo Seo & Gyoo Yeol Jung, 2019. "Vibrio sp. dhg as a platform for the biorefinery of brown macroalgae," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10371-1
    DOI: 10.1038/s41467-019-10371-1
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    Cited by:

    1. Chae Won Kang & Hyun Gyu Lim & Jaehyuk Won & Sanghak Cha & Giyoung Shin & Jae-Seong Yang & Jaeyoung Sung & Gyoo Yeol Jung, 2022. "Circuit-guided population acclimation of a synthetic microbial consortium for improved biochemical production," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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