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Heading direction with respect to a reference point modulates place-cell activity

Author

Listed:
  • P. E. Jercog

    (College of Physicians and Surgeons of Columbia University)

  • Y. Ahmadian

    (University of Oregon)

  • C. Woodruff

    (College of Physicians and Surgeons of Columbia University)

  • R. Deb-Sen

    (College of Physicians and Surgeons of Columbia University)

  • L. F. Abbott

    (College of Physicians and Surgeons of Columbia University
    College of Physicians and Surgeons of Columbia University
    Columbia University
    Columbia University)

  • E. R. Kandel

    (College of Physicians and Surgeons of Columbia University
    College of Physicians and Surgeons of Columbia University
    Columbia University
    Columbia University)

Abstract

The tuning of neurons in area CA1 of the hippocampus emerges through a combination of non-spatial input from different sensory modalities and spatial information about the animal’s position and heading direction relative to the spatial enclosure being navigated. The positional modulation of CA1 neuronal responses has been widely studied (e.g. place tuning), but less is known about the modulation of these neurons by heading direction. Here, utilizing electrophysiological recordings from CA1 pyramidal cells in freely moving mice, we report that a majority of neural responses are modulated by the heading-direction of the animal relative to a point within or outside their enclosure that we call a reference point. The finding of heading-direction modulation relative to reference points identifies a novel representation encoded in the neuronal responses of the dorsal hippocampus.

Suggested Citation

  • P. E. Jercog & Y. Ahmadian & C. Woodruff & R. Deb-Sen & L. F. Abbott & E. R. Kandel, 2019. "Heading direction with respect to a reference point modulates place-cell activity," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10139-7
    DOI: 10.1038/s41467-019-10139-7
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    Cited by:

    1. Omer Hazon & Victor H. Minces & David P. Tomàs & Surya Ganguli & Mark J. Schnitzer & Pablo E. Jercog, 2022. "Noise correlations in neural ensemble activity limit the accuracy of hippocampal spatial representations," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Xiang Zhang & Qichen Cao & Kai Gao & Cong Chen & Sihui Cheng & Ang Li & Yuqian Zhou & Ruojin Liu & Jun Hao & Emilio Kropff & Chenglin Miao, 2024. "Multiplexed representation of others in the hippocampal CA1 subfield of female mice," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Diego B. Piza & Benjamin W. Corrigan & Roberto A. Gulli & Sonia Carmo & A. Claudio Cuello & Lyle Muller & Julio Martinez-Trujillo, 2024. "Primacy of vision shapes behavioral strategies and neural substrates of spatial navigation in marmoset hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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