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Free radical sensors based on inner-cutting graphene field-effect transistors

Author

Listed:
  • Zhen Wang

    (Fudan University
    Fudan University
    Fudan University)

  • Kongyang Yi

    (Fudan University
    Fudan University
    Fudan University)

  • Qiuyuan Lin

    (Fudan University)

  • Lei Yang

    (Fudan University
    Fudan University
    Fudan University)

  • Xiaosong Chen

    (Fudan University
    Fudan University
    Fudan University)

  • Hui Chen

    (Fudan University)

  • Yunqi Liu

    (Fudan University)

  • Dacheng Wei

    (Fudan University
    Fudan University
    Fudan University)

Abstract

Due to ultra-high reactivity, direct determination of free radicals, especially hydroxyl radical (•OH) with ultra-short lifetime, by field-effect transistor (FET) sensors remains a challenge, which hampers evaluating the role that free radical plays in physiological and pathological processes. Here, we develop a •OH FET sensor with a graphene channel functionalized by metal ion indicators. At the electrolyte/graphene interface, highly reactive •OH cuts the cysteamine to release the metal ions, resulting in surface charge de-doping and a current response. By this inner-cutting strategy, the •OH is selectively detected with a concentration down to 10−9 M. Quantitative metal ion doping enables modulation of the device sensitivity and a quasi-quantitative detection of •OH generated in aqueous solution or from living cells. Owing to its high sensitivity, selectivity, real-time label-free response, capability for quasi-quantitative detection and user-friendly portable feature, it is valuable in biological research, human health, environmental monitoring, etc.

Suggested Citation

  • Zhen Wang & Kongyang Yi & Qiuyuan Lin & Lei Yang & Xiaosong Chen & Hui Chen & Yunqi Liu & Dacheng Wei, 2019. "Free radical sensors based on inner-cutting graphene field-effect transistors," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09573-4
    DOI: 10.1038/s41467-019-09573-4
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    Cited by:

    1. Yuyang Shan & Yan Sun & Wanghai Tao & Lijun Su, 2023. "Effects of Oxygenated Brackish Water on Pakchoi ( Brassica chinensis L.) Growth Characteristics Based on a Logistic Crop Growth Model," Agriculture, MDPI, vol. 13(7), pages 1-17, July.

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