IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-09349-w.html
   My bibliography  Save this article

Functional ultrasound imaging of the brain reveals propagation of task-related brain activity in behaving primates

Author

Listed:
  • Alexandre Dizeux

    (PSL Research University)

  • Marc Gesnik

    (PSL Research University)

  • Harry Ahnine

    (Sorbonne Université)

  • Kevin Blaize

    (Sorbonne Université)

  • Fabrice Arcizet

    (Sorbonne Université)

  • Serge Picaud

    (Sorbonne Université)

  • José-Alain Sahel

    (Sorbonne Université
    The University of Pittsburgh School of Medicine)

  • Thomas Deffieux

    (PSL Research University)

  • Pierre Pouget

    (Sorbonne Université)

  • Mickael Tanter

    (PSL Research University)

Abstract

Neuroimaging modalities such as MRI and EEG are able to record from the whole brain, but this comes at the price of either limited spatiotemporal resolution or limited sensitivity. Here, we show that functional ultrasound imaging (fUS) of the brain is able to assess local changes in cerebral blood volume during cognitive tasks, with sufficient temporal resolution to measure the directional propagation of signals. In two macaques, we observed an abrupt transient change in supplementary eye field (SEF) activity when animals were required to modify their behaviour associated with a change of saccade tasks. SEF activation could be observed in a single trial, without averaging. Simultaneous imaging of anterior cingulate cortex and SEF revealed a time delay in the directional functional connectivity of 0.27 ± 0.07 s and 0.9 ± 0.2 s for both animals. Cerebral hemodynamics of large brain areas can be measured at high spatiotemporal resolution using fUS.

Suggested Citation

  • Alexandre Dizeux & Marc Gesnik & Harry Ahnine & Kevin Blaize & Fabrice Arcizet & Serge Picaud & José-Alain Sahel & Thomas Deffieux & Pierre Pouget & Mickael Tanter, 2019. "Functional ultrasound imaging of the brain reveals propagation of task-related brain activity in behaving primates," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09349-w
    DOI: 10.1038/s41467-019-09349-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-09349-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-09349-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yurou Jia & Suying Zhang & Xuan Zhang & Houyou Long & Caibin Xu & Yechao Bai & Ying Cheng & Dajian Wu & Mingxi Deng & Cheng-Wei Qiu & Xiaojun Liu, 2024. "Compact meta-differentiator for achieving isotropically high-contrast ultrasonic imaging," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09349-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.