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Characterization of the hemodynamic response function in white matter tracts for event-related fMRI

Author

Listed:
  • Muwei Li

    (Vanderbilt University Institute of Imaging Science
    Vanderbilt University Medical Center)

  • Allen T. Newton

    (Vanderbilt University Institute of Imaging Science
    Vanderbilt University Medical Center)

  • Adam W. Anderson

    (Vanderbilt University Institute of Imaging Science
    Vanderbilt University Medical Center
    Vanderbilt University)

  • Zhaohua Ding

    (Vanderbilt University Institute of Imaging Science
    Vanderbilt University
    Vanderbilt University)

  • John C. Gore

    (Vanderbilt University Institute of Imaging Science
    Vanderbilt University Medical Center
    Vanderbilt University)

Abstract

Accurate estimates of the BOLD hemodynamic response function (HRF) are crucial for the interpretation and analysis of event-related functional MRI data. To date, however, there have been no comprehensive measurements of the HRF in white matter (WM) despite increasing evidence that BOLD signals in WM change after a stimulus. We performed an event-related cognitive task (Stroop color-word interference) to measure the HRF in selected human WM pathways. The task was chosen in order to produce robust, distributed centers of activity throughout the cortex. To measure the HRF in WM, fiber tracts were reconstructed between each pair of activated cortical areas. We observed clear task-specific HRFs with reduced magnitudes, delayed onsets and prolonged initial dips in WM tracts compared with activated grey matter, thus calling for significant changes to current standard models for accurately characterizing the HRFs in WM and for modifications of standard methods of analysis of functional imaging data.

Suggested Citation

  • Muwei Li & Allen T. Newton & Adam W. Anderson & Zhaohua Ding & John C. Gore, 2019. "Characterization of the hemodynamic response function in white matter tracts for event-related fMRI," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09076-2
    DOI: 10.1038/s41467-019-09076-2
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    Cited by:

    1. Yali Huang & Peng-Hu Wei & Longzhou Xu & Desheng Chen & Yanfeng Yang & Wenkai Song & Yangyang Yi & Xiaoli Jia & Guowei Wu & Qingchen Fan & Zaixu Cui & Guoguang Zhao, 2023. "Intracranial electrophysiological and structural basis of BOLD functional connectivity in human brain white matter," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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