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Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

Author

Listed:
  • Wenting Yang

    (Beijing Institute of Lifeomics)

  • Yuandong Tao

    (Beijing Institute of Lifeomics)

  • Yan Wu

    (Beijing Institute of Lifeomics)

  • Xinyuan Zhao

    (Beijing Institute of Lifeomics)

  • Weijie Ye

    (Beijing Institute of Lifeomics)

  • Dianyuan Zhao

    (Beijing Institute of Lifeomics)

  • Ling Fu

    (Beijing Institute of Lifeomics)

  • Caiping Tian

    (Beijing Institute of Lifeomics)

  • Jing Yang

    (Beijing Institute of Lifeomics)

  • Fuchu He

    (Beijing Institute of Lifeomics)

  • Li Tang

    (Beijing Institute of Lifeomics
    Anhui Medical University)

Abstract

Phagocytes, including neutrophils and macrophages, have been suggested to function in a cooperative way in the initial phase of inflammatory responses, but their interaction and integration in the resolution of inflammation and tissue repair remain unclear. Here we show that neutrophils have crucial functions in liver repair by promoting the phenotypic conversion of pro-inflammatory Ly6ChiCX3CR1lo monocytes/macrophages to pro-resolving Ly6CloCX3CR1hi macrophages. Intriguingly, reactive oxygen species (ROS), expressed predominantly by neutrophils, are important mediators that trigger this phenotypic conversion to promote liver repair. Moreover, this conversion is prevented by the depletion of neutrophils via anti-Ly6G antibody, genetic deficiency of granulocyte colony-stimulating factor, or genetic deficiency of NADPH oxidase 2 (Nox2). By contrast, adoptive transfer of WT rather than Nox2−/− neutrophils rescues the impaired phenotypic conversion of macrophages in neutrophil-depleted mice. Our findings thus identify an intricate cooperation between neutrophils and macrophages that orchestrate resolution of inflammation and tissue repair.

Suggested Citation

  • Wenting Yang & Yuandong Tao & Yan Wu & Xinyuan Zhao & Weijie Ye & Dianyuan Zhao & Ling Fu & Caiping Tian & Jing Yang & Fuchu He & Li Tang, 2019. "Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09046-8
    DOI: 10.1038/s41467-019-09046-8
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    1. Jongmin Woo & Sarah M. Williams & Lye Meng Markillie & Song Feng & Chia-Feng Tsai & Victor Aguilera-Vazquez & Ryan L. Sontag & Ronald J. Moore & Dehong Hu & Hardeep S. Mehta & Joshua Cantlon-Bruce & T, 2021. "High-throughput and high-efficiency sample preparation for single-cell proteomics using a nested nanowell chip," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Flavia A. Graca & Anna Stephan & Benjamin A. Minden-Birkenmaier & Abbas Shirinifard & Yong-Dong Wang & Fabio Demontis & Myriam Labelle, 2023. "Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Muxiong Chen & Zhe Feng & Xiaoxiao Fan & Jun Sun & Weihang Geng & Tianxiang Wu & Jinghao Sheng & Jun Qian & Zhengping Xu, 2022. "Long-term monitoring of intravital biological processes using fluorescent protein-assisted NIR-II imaging," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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