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A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome

Author

Listed:
  • Akira Wiberg

    (University of Oxford, Botnar Research Centre
    University of Oxford, John Radcliffe Hospital
    Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital)

  • Michael Ng

    (University of Oxford, Botnar Research Centre)

  • Annina B. Schmid

    (University of Oxford, John Radcliffe Hospital)

  • Robert W. Smillie

    (University of Oxford, Botnar Research Centre)

  • Georgios Baskozos

    (University of Oxford, John Radcliffe Hospital)

  • Michael V. Holmes

    (Medical Research Council Population Health Research Unit at the University of Oxford
    University of Oxford, Richard Doll Building)

  • K. Künnapuu

    (University of Tartu)

  • R. Mägi

    (University of Tartu)

  • David L. Bennett

    (University of Oxford, John Radcliffe Hospital)

  • Dominic Furniss

    (University of Oxford, Botnar Research Centre
    Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital)

Abstract

Carpal tunnel syndrome (CTS) is a common and disabling condition of the hand caused by entrapment of the median nerve at the level of the wrist. It is the commonest entrapment neuropathy, with estimates of prevalence ranging between 5–10%. Here, we undertake a genome-wide association study (GWAS) of an entrapment neuropathy, using 12,312 CTS cases and 389,344 controls identified in UK Biobank. We discover 16 susceptibility loci for CTS with p

Suggested Citation

  • Akira Wiberg & Michael Ng & Annina B. Schmid & Robert W. Smillie & Georgios Baskozos & Michael V. Holmes & K. Künnapuu & R. Mägi & David L. Bennett & Dominic Furniss, 2019. "A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08993-6
    DOI: 10.1038/s41467-019-08993-6
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    Cited by:

    1. Waheed-Ul-Rahman Ahmed & Sam Kleeman & Michael Ng & Wei Wang & Adam Auton & Regent Lee & Ashok Handa & Krina T. Zondervan & Akira Wiberg & Dominic Furniss, 2022. "Genome-wide association analysis and replication in 810,625 individuals with varicose veins," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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