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Modified carbon nitride nanozyme as bifunctional glucose oxidase-peroxidase for metal-free bioinspired cascade photocatalysis

Author

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  • Peng Zhang

    (Pohang University of Science and Technology (POSTECH))

  • Dengrong Sun

    (Pohang University of Science and Technology (POSTECH))

  • Ara Cho

    (Pohang University of Science and Technology (POSTECH))

  • Seunghyun Weon

    (Pohang University of Science and Technology (POSTECH))

  • Seonggyu Lee

    (Pohang University of Science and Technology (POSTECH))

  • Jinwoo Lee

    (Pohang University of Science and Technology (POSTECH))

  • Jeong Woo Han

    (Pohang University of Science and Technology (POSTECH))

  • Dong-Pyo Kim

    (Pohang University of Science and Technology (POSTECH))

  • Wonyong Choi

    (Pohang University of Science and Technology (POSTECH)
    Pohang University of Science and Technology (POSTECH))

Abstract

Nanomaterials-based biomimetic catalysts with multiple functions are necessary to address challenges in artificial enzymes mimicking physiological processes. Here we report a metal-free nanozyme of modified graphitic carbon nitride and demonstrate its bifunctional enzyme-mimicking roles. With oxidase mimicking, hydrogen peroxide is generated from the coupled photocatalysis of glucose oxidation and dioxygen reduction under visible-light irradiation with a near 100% apparent quantum efficiency. Then, the in situ generated hydrogen peroxide serves for the subsequent peroxidase-mimicking reaction that oxidises a chromogenic substrate on the same catalysts in dark to complete the bifunctional oxidase-peroxidase for biomimetic detection of glucose. The bifunctional cascade catalysis is successfully demonstrated in microfluidics for the real-time colorimetric detection of glucose with a low detection limit of 0.8 μM within 30 s. The artificial nanozymes with physiological functions provide the feasible strategies for mimicking the natural enzymes and realizing the biomedical diagnostics with a smart and miniature device.

Suggested Citation

  • Peng Zhang & Dengrong Sun & Ara Cho & Seunghyun Weon & Seonggyu Lee & Jinwoo Lee & Jeong Woo Han & Dong-Pyo Kim & Wonyong Choi, 2019. "Modified carbon nitride nanozyme as bifunctional glucose oxidase-peroxidase for metal-free bioinspired cascade photocatalysis," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08731-y
    DOI: 10.1038/s41467-019-08731-y
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    Cited by:

    1. Tong Li & Xiaoyu Wang & Yuting Wang & Yihong Zhang & Sirong Li & Wanling Liu & Shujie Liu & Yufeng Liu & Hang Xing & Ken-ichi Otake & Susumu Kitagawa & Jiangjiexing Wu & Hao Dong & Hui Wei, 2024. "Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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