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Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

Author

Listed:
  • Michelle Daya

    (University of Colorado Denver)

  • Nicholas Rafaels

    (University of Colorado Denver)

  • Tonya M. Brunetti

    (University of Colorado Denver)

  • Sameer Chavan

    (University of Colorado Denver)

  • Albert M. Levin

    (Henry Ford Health System)

  • Aniket Shetty

    (University of Colorado Denver)

  • Christopher R. Gignoux

    (University of Colorado Denver)

  • Meher Preethi Boorgula

    (University of Colorado Denver)

  • Genevieve Wojcik

    (Stanford University School of Medicine)

  • Monica Campbell

    (University of Colorado Denver)

  • Candelaria Vergara

    (Johns Hopkins University)

  • Dara G. Torgerson

    (University of California San Francisco)

  • Victor E. Ortega

    (Wake Forest School of Medicine)

  • Ayo Doumatey

    (National Institutes of Health)

  • Henry Richard Johnston

    (Emory University)

  • Nathalie Acevedo

    (Universidad de Cartagena)

  • Maria Ilma Araujo

    (Universidade Federal da Bahia)

  • Pedro C. Avila

    (Northwestern University)

  • Gillian Belbin

    (Icahn School of Medicine at Mount Sinai)

  • Eugene Bleecker

    (University of Arizona College of Medicine)

  • Carlos Bustamante

    (Stanford University School of Medicine)

  • Luis Caraballo

    (Universidad de Cartagena)

  • Alvaro Cruz

    (Universidade Federal da Bahia)

  • Georgia M. Dunston

    (Howard University College of Medicine)

  • Celeste Eng

    (University of California San Francisco)

  • Mezbah U. Faruque

    (Howard University College of Medicine)

  • Trevor S. Ferguson

    (The University of the West Indies)

  • Camila Figueiredo

    (Universidade Federal da Bahia)

  • Jean G. Ford

    (Einstein Medical Center)

  • Weiniu Gan

    (National Institutes of Health)

  • Pierre-Antoine Gourraud

    (Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR)

  • Nadia N. Hansel

    (Johns Hopkins University)

  • Ryan D. Hernandez

    (University of California San Francisco)

  • Edwin Francisco Herrera-Paz

    (Universidad Católica de Honduras
    Universidad Tecnológica Centroamericana (UNITEC), Facultad de Ciencias Médicas)

  • Silvia Jiménez

    (Universidad de Cartagena)

  • Eimear E. Kenny

    (Icahn School of Medicine at Mount Sinai)

  • Jennifer Knight-Madden

    (The University of the West Indies)

  • Rajesh Kumar

    (Northwestern University)

  • Leslie A. Lange

    (University of Colorado Denver)

  • Ethan M. Lange

    (University of Colorado Denver)

  • Antoine Lizee

    (Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR)

  • Pissamai Maul

    (The University of the West Indies, Chronic Disease Research Centre)

  • Trevor Maul

    (The University of the West Indies, Chronic Disease Research Centre)

  • Alvaro Mayorga

    (Centro de Neumologia y Alergias)

  • Deborah Meyers

    (University of Arizona College of Medicine)

  • Dan L. Nicolae

    (University of Chicago)

  • Timothy D. O’Connor

    (University of Maryland School of Medicine)

  • Ricardo Riccio Oliveira

    (Centro de Pesquisas Gonçalo Moniz)

  • Christopher O. Olopade

    (University of Chicago)

  • Olufunmilayo Olopade

    (University of Chicago)

  • Zhaohui S. Qin

    (Emory University)

  • Charles Rotimi

    (National Institutes of Health)

  • Nicolas Vince

    (Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR)

  • Harold Watson

    (The University of the West Indies, Queen Elizabeth Hospital)

  • Rainford J. Wilks

    (The University of the West Indies)

  • James G. Wilson

    (University of Mississippi Medical Center)

  • Steven Salzberg

    (Johns Hopkins University)

  • Carole Ober

    (University of Chicago)

  • Esteban G. Burchard

    (University of California San Francisco)

  • L. Keoki Williams

    (Henry Ford Health System)

  • Terri H. Beaty

    (Bloomberg School of Public Health, JHU)

  • Margaret A. Taub

    (Bloomberg School of Public Health, JHU)

  • Ingo Ruczinski

    (Bloomberg School of Public Health, JHU)

  • Rasika A. Mathias

    (Johns Hopkins University)

  • Kathleen C. Barnes

    (University of Colorado Denver)

Abstract

Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12–q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.

Suggested Citation

  • Michelle Daya & Nicholas Rafaels & Tonya M. Brunetti & Sameer Chavan & Albert M. Levin & Aniket Shetty & Christopher R. Gignoux & Meher Preethi Boorgula & Genevieve Wojcik & Monica Campbell & Candelar, 2019. "Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08469-7
    DOI: 10.1038/s41467-019-08469-7
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    Cited by:

    1. Ivy Aneas & Donna C. Decker & Chanie L. Howard & Débora R. Sobreira & Noboru J. Sakabe & Kelly M. Blaine & Michelle M. Stein & Cara L. Hrusch & Lindsey E. Montefiori & Juan Tena & Kevin M. Magnaye & S, 2021. "Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Brooke Szczesny & Meher Preethi Boorgula & Sameer Chavan & Monica Campbell & Randi K. Johnson & Kai Kammers & Emma E. Thompson & Madison S. Cox & Gautam Shankar & Corey Cox & Andréanne Morin & Wendy L, 2024. "Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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