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Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system

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  • Phing Chian Chai

    (University of Lausanne)

  • Steeve Cruchet

    (University of Lausanne)

  • Leonore Wigger

    (University of Lausanne
    SIB Swiss Institute of Bioinformatics)

  • Richard Benton

    (University of Lausanne)

Abstract

Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-probe specific lineages, especially at early developmental stages prior to expression of unique molecular markers. Here, we use a genetic immortalization method to analyze the development of sensory neuron lineages in the Drosophila olfactory system, from their origin to terminal differentiation. We apply this approach to define a fate map of nearly all olfactory lineages and refine the model of temporal patterns of lineage divisions. Taking advantage of a selective marker for the lineage that gives rise to Or67d pheromone-sensing neurons and a genome-wide transcription factor RNAi screen, we identify the spatial and temporal requirements for Pointed, an ETS family member, in this developmental pathway. Transcriptomic analysis of wild-type and Pointed-depleted olfactory tissue reveals a universal requirement for this factor as a switch-like determinant of fates in these sensory lineages.

Suggested Citation

  • Phing Chian Chai & Steeve Cruchet & Leonore Wigger & Richard Benton, 2019. "Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08345-4
    DOI: 10.1038/s41467-019-08345-4
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    Cited by:

    1. Suguru Takagi & Gizem Sancer & Liliane Abuin & S. David Stupski & J. Roman Arguello & Lucia L. Prieto-Godino & David L. Stern & Steeve Cruchet & Raquel Álvarez-Ocaña & Carl F. R. Wienecke & Floris Bre, 2024. "Olfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Gwénaëlle Bontonou & Bastien Saint-Leandre & Tane Kafle & Tess Baticle & Afrah Hassan & Juan Antonio Sánchez-Alcañiz & J. Roman Arguello, 2024. "Evolution of chemosensory tissues and cells across ecologically diverse Drosophilids," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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