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Defect engineered bioactive transition metals dichalcogenides quantum dots

Author

Listed:
  • Xianguang Ding

    (National University of Singapore
    National University of Singapore)

  • Fei Peng

    (National University of Singapore)

  • Jun Zhou

    (National University of Singapore)

  • Wenbin Gong

    (Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences)

  • Garaj Slaven

    (National University of Singapore
    National University of Singapore)

  • Kian Ping Loh

    (National University of Singapore
    National University of Singapore)

  • Chwee Teck Lim

    (National University of Singapore
    National University of Singapore
    Mechanobiology Institute, Mechanobiology Institute
    Biomedical Institute for Global Health Research and Technology)

  • David Tai Leong

    (National University of Singapore)

Abstract

Transition metal dichalcogenide (TMD) quantum dots (QDs) are fundamentally interesting because of the stronger quantum size effect with decreased lateral dimensions relative to their larger 2D nanosheet counterparts. However, the preparation of a wide range of TMD QDs is still a continual challenge. Here we demonstrate a bottom-up strategy utilizing TM oxides or chlorides and chalcogen precursors to synthesize a small library of TMD QDs (MoS2, WS2, RuS2, MoTe2, MoSe2, WSe2 and RuSe2). The reaction reaches equilibrium almost instantaneously (~10–20 s) with mild aqueous and room temperature conditions. Tunable defect engineering can be achieved within the same reactions by deviating the precursors’ reaction stoichiometries from their fixed molecular stoichiometries. Using MoS2 QDs for proof-of-concept biomedical applications, we show that increasing sulfur defects enhanced oxidative stress generation, through the photodynamic effect, in cancer cells. This facile strategy will motivate future design of TMDs nanomaterials utilizing defect engineering for biomedical applications.

Suggested Citation

  • Xianguang Ding & Fei Peng & Jun Zhou & Wenbin Gong & Garaj Slaven & Kian Ping Loh & Chwee Teck Lim & David Tai Leong, 2019. "Defect engineered bioactive transition metals dichalcogenides quantum dots," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-07835-1
    DOI: 10.1038/s41467-018-07835-1
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    Cited by:

    1. Xiaoying Kang & Yuan Zhang & Jianwen Song & Lu Wang & Wen Li & Ji Qi & Ben Zhong Tang, 2023. "A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Bang Lin Li & Jun Jiang Luo & Hao Lin Zou & Qing-Meng Zhang & Liu-Bin Zhao & Hang Qian & Hong Qun Luo & David Tai Leong & Nian Bing Li, 2022. "Chiral nanocrystals grown from MoS2 nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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