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Toxicological Response of Zebrafish Exposed to Cocktails of Polymeric Materials and Valproic Acid

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  • Alexandra Savuca

    (Doctoral School of Geosciences, Faculty of Geography and Geology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania
    Doctoral School of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania)

  • Ionut-Alexandru Chelaru

    (Doctoral School of Geosciences, Faculty of Geography and Geology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania
    Doctoral School of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania)

  • Ioana-Miruna Balmus

    (Doctoral School of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania
    Department of Exact Sciences and Natural Sciences, Institute of Interdisciplinary Research, “Alexandru Ioan Cuza” University of Iasi, Alexandru Lapusneanu Street, 26, 700057 Iasi, Romania)

  • Alexandrina-Stefania Curpan

    (Doctoral School of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania)

  • Mircea Nicusor Nicoara

    (Doctoral School of Geosciences, Faculty of Geography and Geology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania
    Department of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania)

  • Alin Stelian Ciobica

    (Department of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iași, Carol I Avenue, 20A, 700505 Iași, Romania
    Center of Biomedical Research, Romanian Academy, Iasi Branch, Teodor Codrescu 2, 700481 Iasi, Romania
    Academy of Romanian Scientists, 3 Ilfov, 050044 Bucharest, Romania
    Preclinical Department, Apollonia University, 700511 Iasi, Romania)

Abstract

Microplastic pollution represents an emerging problem of great interest in the public domain in the last decade; in addition, it overlaps with another delicate problem—pollution with pharmaceutical products that can have negative effects on the environment and people, even in small amounts. The main purpose of this study was to assess the biochemical and behavioral effects of exposure of adult zebrafish ( Danio rerio ) to polyethylene (PE), polypropylene (PP) and valproic acid (VPA), respectively to their mixtures—possible situations in natural aquatic environments. In terms of behavioral responses, sociability appears to be more impaired in the PP group after 5 days of exposure. The mechanisms affected are more those of swimming performance than of sociability. Even more, VPA increases presence in the arm with conspecifics but decreases mobility and locomotion, indicating a possible anxiety mechanism. The mixtures decrease the aggressiveness, especially in the case of the PE+VPA group, where it reaches a super low level compared to the control, which could endanger the species in nature. Regarding the anxiogenic effect, PP and PE act differently: if PE has an anxiogenic effect, on the opposite side is the PP group, which shows a bolder and more agitated behavior. All four variants showed behavioral changes indicative of toxicity from the first dose.

Suggested Citation

  • Alexandra Savuca & Ionut-Alexandru Chelaru & Ioana-Miruna Balmus & Alexandrina-Stefania Curpan & Mircea Nicusor Nicoara & Alin Stelian Ciobica, 2024. "Toxicological Response of Zebrafish Exposed to Cocktails of Polymeric Materials and Valproic Acid," Sustainability, MDPI, vol. 16(5), pages 1-14, March.
    • Handle: RePEc:gam:jsusta:v:16:y:2024:i:5:p:2057-:d:1349731
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    References listed on IDEAS

    as
    1. Yu, Jim T. & Bouwer, Edward J. & Coelhan, Mehmet, 2006. "Occurrence and biodegradability studies of selected pharmaceuticals and personal care products in sewage effluent," Agricultural Water Management, Elsevier, vol. 86(1-2), pages 72-80, November.
    2. Meghana Desai & Anuli Njoku & Lillian Nimo-Sefah, 2022. "Comparing Environmental Policies to Reduce Pharmaceutical Pollution and Address Disparities," IJERPH, MDPI, vol. 19(14), pages 1-15, July.
    Full references (including those not matched with items on IDEAS)

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