Impact of the 1742–1743 Plague Epidemic on Global Excess Deaths and Social Dynamics in the City of Córdoba and Along the Camino Real Between Buenos Aires and Lima

The 1742–1743 plague epidemic profoundly impacted populations along the Camino Real, the main colonial trade route connecting Buenos Aires and Lima, with Córdoba, Argentina, as a critical focal point. This research examines the multidimensional repercussions of the epidemic, emphasizing its demographic, social, and economic consequences. Utilizing parish records as primary sources, this study quantifies the excess mortality, revealing a dramatic increase, with death rates in Córdoba peaking at 12 times the pre-epidemic average in May 1743. Marginalized groups, particularly enslaved and Indigenous populations, were disproportionately affected, which exacerbated existing social inequalities. Through a comprehensive analysis of historical data, this study contributes to understanding epidemic responses in colonial Latin America, illuminating how public health crises intersect with demographic and socio-economic structures. The findings provide insights that are relevant to contemporary public health perspectives on crisis management and resilience, highlighting how historical epidemics offer valuable understanding into the social dynamics of health emergencies.