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Finite-Element Method for the Simulation of Lipid Vesicle/Fluid Interactions in a Quasi–Newtonian Fluid Flow

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  • Aymen Laadhari

    (Department of Mathematics, College of Arts and Sciences, Khalifa University of Science and Technology, Abu Dhabi P.O. Box 127788, United Arab Emirates)

Abstract

We present a computational framework for modeling an inextensible single vesicle driven by the Helfrich force in an incompressible, non-Newtonian extracellular Carreau fluid. The vesicle membrane is captured with a level set strategy. The local inextensibility constraint is relaxed by introducing a penalty which allows computational savings and facilitates implementation. A high-order Galerkin finite element approximation allows accurate calculations of the membrane force with high-order derivatives. The time discretization is based on the double composition of the one-step backward Euler scheme, while the time step size is flexibly controlled using a time integration error estimation. Numerical examples are presented with particular attention paid to the validation and assessment of the model’s relevance in terms of physiological significance. Optimal convergence rates of the time discretization are obtained.

Suggested Citation

  • Aymen Laadhari, 2023. "Finite-Element Method for the Simulation of Lipid Vesicle/Fluid Interactions in a Quasi–Newtonian Fluid Flow," Mathematics, MDPI, vol. 11(8), pages 1-18, April.
    • Handle: RePEc:gam:jmathe:v:11:y:2023:i:8:p:1950-:d:1128718
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    References listed on IDEAS

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    1. Laadhari, Aymen, 2018. "Implicit finite element methodology for the numerical modeling of incompressible two-fluid flows with moving hyperelastic interface," Applied Mathematics and Computation, Elsevier, vol. 333(C), pages 376-400.
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