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Central Apnea in Patients with COVID-19 Infection

Author

Listed:
  • Vikram Venkata Puram

    (Department of Medicine, Stanford University, Stanford, CA 94305, USA)

  • Anish Sethi

    (School of Medicine, Drexel University, Philadelphia, PA 19104, USA)

  • Olga Epstein

    (Department of Internal Medicine, VA Medical Center, Minneapolis, MN 55417, USA)

  • Malik Ghannam

    (Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA)

  • Kevin Brown

    (Department of Neurology, VA Medical Center, Minneapolis, MN 55417, USA)

  • James Ashe

    (Department of Neurology, VA Medical Center, Minneapolis, MN 55417, USA)

  • Brent Berry

    (Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Department of Neurology, Department of Sleep Medicine, Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA)

Abstract

Background: The Coronavirus Disease 2019 (COVID-19) is a global pandemic that has killed over 1.5 million people worldwide. A constellation of multisystem involvement with SARS-CoV-2 has been reported. COVID-19 has been shown to affect the human nervous system, however, both the extent and severity of involvement have yet to be fully elucidated. In this manuscript, we aimed to better understand the effect of COVID-19 on neuro-respiratory status by studying COVID-19 patients who presented with central apnea. Methodology: We analyzed patient characteristics, clinical outcomes, laboratory results, and imaging results of three patients with symptomatic, PCR-proven COVID-19 and episodes of central apnea. Results: Of the three patients included in this study, two patients developed new central apnea, and one patient developed an exacerbation of underlying central apnea despite COVID-19 treatments with systemic steroids and remdesivir. All occurred, on average, 15 days after the onset of COVID-19 symptoms. At 1-year follow-up, all patients experienced complete resolution of apneic breathing. Conclusions: Physicians should be vigilant for the presentation of COVID-19 with central apnea. Central apnea may be a complication in patients with severe COVID-19 infection. More research is warranted to further understand this association.

Suggested Citation

  • Vikram Venkata Puram & Anish Sethi & Olga Epstein & Malik Ghannam & Kevin Brown & James Ashe & Brent Berry, 2023. "Central Apnea in Patients with COVID-19 Infection," J, MDPI, vol. 6(1), pages 1-8, March.
    • Handle: RePEc:gam:jjopen:v:6:y:2023:i:1:p:12-171:d:1086547
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    Cited by:

    1. Maria Vasiliki Sanida & Theodora Sanida & Argyrios Sideris & Minas Dasygenis, 2024. "An Advanced Deep Learning Framework for Multi-Class Diagnosis from Chest X-ray Images," J, MDPI, vol. 7(1), pages 1-24, January.
    2. Theodora Sanida & Maria Vasiliki Sanida & Argyrios Sideris & Minas Dasygenis, 2024. "Enhancing Pulmonary Diagnosis in Chest X-rays through Generative AI Techniques," J, MDPI, vol. 7(3), pages 1-17, August.

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