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Antihypertensives’ Rock around the Clock

Author

Listed:
  • Ognjenka Rahić

    (Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina)

  • Amina Tucak

    (Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina)

  • Merima Sirbubalo

    (Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina)

  • Lamija Hindija

    (Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina)

  • Jasmina Hadžiabdić

    (Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina)

Abstract

Although homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable and that variability occurs in cycles. In order to explain and understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model has emerged as the first serious challenge to homeostasis, going beyond its homeostatic roots. Circadian rhythm is the predominant variation in the body, and it is a pattern according to which many physiological and pathological events occur. As there is strong experimental and clinical evidence that blood pressure fluctuations undergo circadian rhythm, there is equally strong evidence that targeted time therapy for hypertension provides a better outcome of the disease. The research has gone even further throughout the development and approval process for the use of pulsatile drug release systems, which can be considered as an option for an even more convenient dosage regimen of the medicines needed.

Suggested Citation

  • Ognjenka Rahić & Amina Tucak & Merima Sirbubalo & Lamija Hindija & Jasmina Hadžiabdić, 2021. "Antihypertensives’ Rock around the Clock," J, MDPI, vol. 4(1), pages 1-20, March.
    • Handle: RePEc:gam:jjopen:v:4:y:2021:i:1:p:5-81:d:520072
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    References listed on IDEAS

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    1. Maria Casagrande & Francesca Favieri & Viviana Langher & Angela Guarino & Enrico Di Pace & Giuseppe Germanò & Giuseppe Forte, 2020. "The Night Side of Blood Pressure: Nocturnal Blood Pressure Dipping and Emotional (dys)Regulation," IJERPH, MDPI, vol. 17(23), pages 1-11, November.
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