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Endocrine Disruptors and Obesity: An Examination of Selected Persistent Organic Pollutants in the NHANES 1999–2002 Data

Author

Listed:
  • Mai A. Elobeid

    (Department of Biostatistics, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL, 35294, USA
    Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA)

  • Miguel A. Padilla

    (Department of Psychology, Old Dominion University, 250 Mills Godwin Building, Norfolk, VA 23529, USA
    Department of Mathematics and Statistics, Old Dominion University, 250 Mills Godwin Building, Norfolk, VA 23529, USA)

  • David W. Brock

    (Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA)

  • Douglas M. Ruden

    (Institute of Environmental Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA)

  • David B. Allison

    (Department of Biostatistics, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL, 35294, USA
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA
    Clinical Nutrition Research Center, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294, USA)

Abstract

Recent evidence suggests that endocrine disrupting chemicals (EDCs) may cause perturbations in endogenous hormonal regulation that predispose to weight gain. Using data from NHANES (1999–2002), we investigated the association between body mass index (BMI), waist circumference (WC) and selected persistent organic pollutants (POPs) via multiple linear regressions. Consistent interaction was found between gender, ln oxychlordane and ln p,p’ DDT. Also, we found an association between WC and ln oxychlordane and ln hpcdd in subjects with detectable levels of POPs, whereas an association between WC and ln p,p’ DDT was observed in all subjects. Furthermore, ln Ocdd showed an increase with higher WC and BMI, whereas, ln trans-nonachlor decreased with higher BMI. Hence, BMI and WC are associated with POPs levels, making the chemicals plausible contributors to the obesity epidemic.

Suggested Citation

  • Mai A. Elobeid & Miguel A. Padilla & David W. Brock & Douglas M. Ruden & David B. Allison, 2010. "Endocrine Disruptors and Obesity: An Examination of Selected Persistent Organic Pollutants in the NHANES 1999–2002 Data," IJERPH, MDPI, vol. 7(7), pages 1-18, July.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:7:p:2988-3005:d:9064
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    Citations

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    Cited by:

    1. Alexander V. Sergeev & David O. Carpenter, 2011. "Increase in Metabolic Syndrome-Related Hospitalizations in Relation to Environmental Sources of Persistent Organic Pollutants," IJERPH, MDPI, vol. 8(3), pages 1-15, March.
    2. Zarish Noreen & Christopher A. Loffredo & Attya Bhatti & Jyothirmai J. Simhadri & Gail Nunlee-Bland & Thomas Nnanabu & Peter John & Jahangir S. Khan & Somiranjan Ghosh, 2020. "Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population," IJERPH, MDPI, vol. 17(16), pages 1-20, August.

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