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Alcoholism and Alternative Splicing of Candidate Genes

Author

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  • Toshikazu Sasabe

    (Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan)

  • Shoichi Ishiura

    (Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan)

Abstract

Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor) may form the basis of the mechanisms underlying the pathophysiology of alcoholism. These reports suggest that aberrant expression of splice variants affects alcohol sensitivities, and alcohol consumption also regulates alternative splicing. Thus, investigations of alternative splicing are essential for understanding the molecular events underlying the development of alcoholism.

Suggested Citation

  • Toshikazu Sasabe & Shoichi Ishiura, 2010. "Alcoholism and Alternative Splicing of Candidate Genes," IJERPH, MDPI, vol. 7(4), pages 1-19, March.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:4:p:1448-1466:d:7700
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    References listed on IDEAS

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    1. S. John Mihic & Qing Ye & Marilee J. Wick & Vladimir V. Koltchine & Matthew D. Krasowski & Suzanne E. Finn & Maria Paola Mascia & C. Fernando Valenzuela & Kirsten K. Hanson & Eric P. Greenblatt & R. A, 1997. "Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors," Nature, Nature, vol. 389(6649), pages 385-389, September.
    2. Alessandro Usiello & Ja-Hyun Baik & Françoise Rougé-Pont & Roberto Picetti & Andrée Dierich & Marianne LeMeur & Pier Vincenzo Piazza & Emiliana Borrelli, 2000. "Distinct functions of the two isoforms of dopamine D2 receptors," Nature, Nature, vol. 408(6809), pages 199-203, November.
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