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Quality of Oral Anticoagulation Control with Warfarin According to Sex: A Cross-Sectional Study

Author

Listed:
  • Catiane Costa Viana

    (Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil)

  • Marcus Fernando da Silva Praxedes

    (Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil
    Centro de Ciências da Saúde, Universidade Federal do Recôncavo da Bahia, Santo Antônio de Jesus 44430-622, Bahia, Brazil)

  • Mauro Henrique Nogueira Guimarães de Abreu

    (Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil)

  • Waleska Jaclyn Freitas Nunes de Sousa

    (Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Minas Gerais, Brazil
    Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Minas Gerais, Brazil)

  • Cássia Rodrigues Lima Ferreira

    (Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Minas Gerais, Brazil
    Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Minas Gerais, Brazil)

  • Emílio Itamar de Freitas Campos

    (Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil)

  • José Luiz Padilha da Silva

    (Departamento de Estatística, Universidade Federal do Paraná, Curitiba 81531-980, Paraná, Brazil)

  • Maria Auxiliadora Parreiras Martins

    (Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil
    Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Minas Gerais, Brazil
    Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte 30130-100, Minas Gerais, Brazil
    Hospital Risoleta Tolentino Neves, Belo Horizonte 31744-012, Minas Gerais, Brazil)

Abstract

Evidence indicates a difference between men and women in oral anticoagulation control, but the results were discrepant. This study investigated the association of sex with oral anticoagulation control in patients on warfarin assisted by anticoagulation clinics (ACs) in Brazil. The cross-sectional study included patients on warfarin recruited at three public ACs in southeast Brazil (2014–2015). The quality of oral anticoagulation was estimated by the time in therapeutic range (TTR). Univariable and multivariable linear regression models were built to examine the association of sociodemographic, behavior, clinical, and drug therapy variables with TTR. Overall, 801 participants were studied (455; 56.8% women), with a mean age of 65.0 (13.4) years. The female sex was associated with lower TTR than the male sex (Beta (95% CI) = −17.01 (−30.25; −3.76), p = 0.012), however, this difference decreased with increasing age, becoming null after age 60. Smoking patients had a lower TTR than non-smokers (−5.18 (−10.02; −0.34), p = 0.036). The results showed that the association of sex with oral anticoagulation control is dependent on age. Women have lower TTR than men, but this difference is null in older patients. Knowledge of these factors may be useful for developing strategies to improve care for these patients.

Suggested Citation

  • Catiane Costa Viana & Marcus Fernando da Silva Praxedes & Mauro Henrique Nogueira Guimarães de Abreu & Waleska Jaclyn Freitas Nunes de Sousa & Cássia Rodrigues Lima Ferreira & Emílio Itamar de Freitas, 2025. "Quality of Oral Anticoagulation Control with Warfarin According to Sex: A Cross-Sectional Study," IJERPH, MDPI, vol. 22(1), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:22:y:2025:i:1:p:65-:d:1560887
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    References listed on IDEAS

    as
    1. Mª Rosa Dalmau Llorca & Carina Aguilar Martín & Noèlia Carrasco-Querol & Zojaina Hernández Rojas & Emma Forcadell Drago & Dolores Rodríguez Cumplido & Elisabet Castro Blanco & Josep Mª Pepió Vilaubí &, 2021. "Gender and Socioeconomic Inequality in the Prescription of Direct Oral Anticoagulants in Patients with Non-Valvular Atrial Fibrillation in Primary Care in Catalonia (Fantas-TIC Study)," IJERPH, MDPI, vol. 18(20), pages 1-12, October.
    2. Mark Woodward, 2019. "Cardiovascular Disease and the Female Disadvantage," IJERPH, MDPI, vol. 16(7), pages 1-13, April.
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