IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v21y2024i3p322-d1354442.html
   My bibliography  Save this article

Potential Risk Factors to COVID-19 Severity: Comparison of SARS-CoV-2 Delta- and Omicron-Dominant Periods

Author

Listed:
  • Daiki Yamaguchi

    (Department of Public Health and Health Policy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan)

  • Odgerel Chimed-Ochir

    (Department of Public Health and Health Policy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan)

  • Yui Yumiya

    (Department of Public Health and Health Policy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan)

  • Eisaku Kishita

    (Medical Economics Division, Health Insurance Bureau, Ministry of Health, Labour and Welfare, Tokyo 100-8916, Japan)

  • Tomoyuki Akita

    (Department of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan)

  • Junko Tanaka

    (Medical Policy Office, Hiroshima University, Hiroshima 734-8553, Japan)

  • Tatsuhiko Kubo

    (Department of Public Health and Health Policy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan)

Abstract

Background: Continued study of risk factors can inform future pandemic preparedness and response. We aimed to determine the potential risk factors of COVID-19 severity among patients admitted to the hospital during the Delta- and Omicron-dominant periods. Methods: We utilized the J-SPEED-style COVID-19 Hospital version, a pre-administered questionnaire, to collect data from hospitals in Hiroshima Prefecture between 8 August 2021 and 19 April 2022. Results: During the Delta-dominant period, patients aged over 65 (OR = 2.59, 95% CI = 1.75–3.84), males (OR = 1.42, 95% CI = 1.12–1.81) and with BMI exceeding 25 (OR = 1.99, 95% CI = 1.57–2.52), diabetes (OR = 2.03, 95% CI = 1.40–2.95), and those with fewer than two doses of vaccine (OR = 2.39, 95% CI = 1.46–3.91) were at a greater risk of severe COVID-19 compared to those without these risk factors. During the Omicron-dominant period, significantly greater severity was observed among patients over 65 years old (OR = 3.89, 95% CI = 2.95–5.12), males (OR = 1.76, 95% CI = 1.40–2.21), those with high blood pressure (OR = 1.30, 95% CI = 1.02–1.65), and mental disorder (OR = 2.22, 95% CI = 1.69–2.92) compared to patients without these risks. Conclusions: Our findings indicate that risk factors vary across different SARS-CoV-2 variants. Examining variant-specific risk factors for COVID-19 severity can aid policymakers, public health specialists, and clinicians in prioritizing screening, treatment, and vaccination efforts, especially during potential healthcare resource shortages.

Suggested Citation

  • Daiki Yamaguchi & Odgerel Chimed-Ochir & Yui Yumiya & Eisaku Kishita & Tomoyuki Akita & Junko Tanaka & Tatsuhiko Kubo, 2024. "Potential Risk Factors to COVID-19 Severity: Comparison of SARS-CoV-2 Delta- and Omicron-Dominant Periods," IJERPH, MDPI, vol. 21(3), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:3:p:322-:d:1354442
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/21/3/322/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/21/3/322/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Peng Zhou & Xing-Lou Yang & Xian-Guang Wang & Ben Hu & Lei Zhang & Wei Zhang & Hao-Rui Si & Yan Zhu & Bei Li & Chao-Lin Huang & Hui-Dong Chen & Jing Chen & Yun Luo & Hua Guo & Ren-Di Jiang & Mei-Qin L, 2020. "Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin," Nature, Nature, vol. 588(7836), pages 6-6, December.
    2. Peng Zhou & Xing-Lou Yang & Xian-Guang Wang & Ben Hu & Lei Zhang & Wei Zhang & Hao-Rui Si & Yan Zhu & Bei Li & Chao-Lin Huang & Hui-Dong Chen & Jing Chen & Yun Luo & Hua Guo & Ren-Di Jiang & Mei-Qin L, 2020. "A pneumonia outbreak associated with a new coronavirus of probable bat origin," Nature, Nature, vol. 579(7798), pages 270-273, March.
    3. Mana Sugimura & Odgerel Chimed-Ochir & Yui Yumiya & Hiroki Ohge & Nobuaki Shime & Takemasa Sakaguchi & Junko Tanaka & Toshiro Takafuta & Michi Mimori & Masao Kuwabara & Toshimasa Asahara & Eisaku Kish, 2021. "The Association between Wearing a Mask and COVID-19," IJERPH, MDPI, vol. 18(17), pages 1-7, August.
    4. Delphine Planas & David Veyer & Artem Baidaliuk & Isabelle Staropoli & Florence Guivel-Benhassine & Maaran Michael Rajah & Cyril Planchais & Françoise Porrot & Nicolas Robillard & Julien Puech & Matth, 2021. "Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization," Nature, Nature, vol. 596(7871), pages 276-280, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Bruno A. Rodriguez-Rodriguez & Grace O. Ciabattoni & Ralf Duerr & Ana M. Valero-Jimenez & Stephen T. Yeung & Keaton M. Crosse & Austin R. Schinlever & Lucie Bernard-Raichon & Joaquin Rodriguez Galvan , 2023. "A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Lei Peng & Yingxia Hu & Madeleine C. Mankowski & Ping Ren & Rita E. Chen & Jin Wei & Min Zhao & Tongqing Li & Therese Tripler & Lupeng Ye & Ryan D. Chow & Zhenhao Fang & Chunxiang Wu & Matthew B. Dong, 2022. "Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Xiaoqi Yu & Dong Wei & Wenxin Xu & Chuanmiao Liu & Wentian Guo & Xinxin Li & Wei Tan & Leshan Liu & Xinxin Zhang & Jieming Qu & Zhitao Yang & Erzhen Chen, 2022. "Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    4. Jun-Yu Si & Yuan-Mei Chen & Ye-Hui Sun & Meng-Xue Gu & Mei-Ling Huang & Lu-Lu Shi & Xiao Yu & Xiao Yang & Qing Xiong & Cheng-Bao Ma & Peng Liu & Zheng-Li Shi & Huan Yan, 2024. "Sarbecovirus RBD indels and specific residues dictating multi-species ACE2 adaptiveness," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    5. Shahadat Uddin & Arif Khan & Haohui Lu & Fangyu Zhou & Shakir Karim, 2022. "Suburban Road Networks to Explore COVID-19 Vulnerability and Severity," IJERPH, MDPI, vol. 19(4), pages 1-9, February.
    6. Kirsten R.C. Hensgens & Inge H.T. van Rensen & Anita W. Lekx & Frits H.M. van Osch & Lieve H.H. Knarren & Caroline E. Wyers & Joop P. van den Bergh & Dennis G. Barten, 2021. "Sort and Sieve: Pre-Triage Screening of Patients with Suspected COVID-19 in the Emergency Department," IJERPH, MDPI, vol. 18(17), pages 1-11, September.
    7. Quan-Hoang Vuong & Tam-Tri Le & Viet-Phuong La & Huyen Thanh Thanh Nguyen & Manh-Toan Ho & Quy Khuc & Minh-Hoang Nguyen, 2022. "Covid-19 vaccines production and societal immunization under the serendipity-mindsponge-3D knowledge management theory and conceptual framework," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-12, December.
    8. Hengrui Liu & Sho Iketani & Arie Zask & Nisha Khanizeman & Eva Bednarova & Farhad Forouhar & Brandon Fowler & Seo Jung Hong & Hiroshi Mohri & Manoj S. Nair & Yaoxing Huang & Nicholas E. S. Tay & Sumin, 2022. "Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    9. Graziella Orrù & Ciro Conversano & Eleonora Malloggi & Francesca Francesconi & Rebecca Ciacchini & Angelo Gemignani, 2020. "Neurological Complications of COVID-19 and Possible Neuroinvasion Pathways: A Systematic Review," IJERPH, MDPI, vol. 17(18), pages 1-18, September.
    10. Gleidson Sobreira Leite & Adriano Bessa Albuquerque & Plácido Rogerio Pinheiro, 2021. "Applications of Technological Solutions in Primary Ways of Preventing Transmission of Respiratory Infectious Diseases—A Systematic Literature Review," IJERPH, MDPI, vol. 18(20), pages 1-50, October.
    11. Britton Boras & Rhys M. Jones & Brandon J. Anson & Dan Arenson & Lisa Aschenbrenner & Malina A. Bakowski & Nathan Beutler & Joseph Binder & Emily Chen & Heather Eng & Holly Hammond & Jennifer Hammond , 2021. "Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    12. Susanne Kessler & Bradly Burke & Geoffroy Andrieux & Jan Schinköthe & Lea Hamberger & Johannes Kacza & Shijun Zhan & Clara Reasoner & Taru S. Dutt & Maria Kaukab Osman & Marcela Henao-Tamayo & Julian , 2024. "Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    13. Yongzhu Xiong & Yunpeng Wang & Feng Chen & Mingyong Zhu, 2020. "Spatial Statistics and Influencing Factors of the COVID-19 Epidemic at Both Prefecture and County Levels in Hubei Province, China," IJERPH, MDPI, vol. 17(11), pages 1-26, May.
    14. Eugene Song & Jae-Eun Lee & Seola Kwon, 2021. "Effect of Public Empathy with Infection-Control Guidelines on Infection-Prevention Attitudes and Behaviors: Based on the Case of COVID-19," IJERPH, MDPI, vol. 18(24), pages 1-18, December.
    15. Fabiana Fiasca & Mauro Minelli & Dominga Maio & Martina Minelli & Ilaria Vergallo & Stefano Necozione & Antonella Mattei, 2020. "Associations between COVID-19 Incidence Rates and the Exposure to PM2.5 and NO 2 : A Nationwide Observational Study in Italy," IJERPH, MDPI, vol. 17(24), pages 1-10, December.
    16. Małgorzata Dudzińska & Marta Gwiaździńska-Goraj & Aleksandra Jezierska-Thöle, 2022. "Social Factors as Major Determinants of Rural Development Variation for Predicting Epidemic Vulnerability: A Lesson for the Future," IJERPH, MDPI, vol. 19(21), pages 1-24, October.
    17. James, Nick & Menzies, Max, 2023. "Collective infectivity of the pandemic over time and association with vaccine coverage and economic development," Chaos, Solitons & Fractals, Elsevier, vol. 176(C).
    18. Jaeyong Lee & Calem Kenward & Liam J. Worrall & Marija Vuckovic & Francesco Gentile & Anh-Tien Ton & Myles Ng & Artem Cherkasov & Natalie C. J. Strynadka & Mark Paetzel, 2022. "X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    19. Xu, Baochang & Li, Sihui & Afzal, Ayesha & Mirza, Nawazish & Zhang, Meng, 2022. "The impact of financial development on environmental sustainability: A European perspective," Resources Policy, Elsevier, vol. 78(C).
    20. Leili Mohammadi & Ahmad Mehravaran & Zahra Derakhshan & Ehsan Gharehchahi & Elza Bontempi & Mohammad Golaki & Razieh Khaksefidi & Mohadeseh Motamed-Jahromi & Mahsa Keshtkar & Amin Mohammadpour & Hamid, 2022. "Investigating the Role of Environmental Factors on the Survival, Stability, and Transmission of SARS-CoV-2, and Their Contribution to COVID-19 Outbreak: A Review," Sustainability, MDPI, vol. 14(18), pages 1-16, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:21:y:2024:i:3:p:322-:d:1354442. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.