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Effects of E-Cigarette (e-cig) Aerosols on Mutagenesis in Selected Organs in a C57 lacI (BigBlue TM ) Mouse Model

Author

Listed:
  • Dweet Chhaya

    (Division of Environmental Medicine, Grossman School of Medicine, New York University, New York, NY 10016, USA)

  • Merna Gress

    (Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48104, USA)

  • Amna Raja

    (Division of Environmental Medicine, Grossman School of Medicine, New York University, New York, NY 10016, USA)

  • Wieslawa Kosinska

    (Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010, USA)

  • Terry Gordon

    (Division of Environmental Medicine, Grossman School of Medicine, New York University, New York, NY 10016, USA)

  • Judith Zelikoff

    (Division of Environmental Medicine, Grossman School of Medicine, New York University, New York, NY 10016, USA)

  • Joseph B. Guttenplan

    (Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010, USA)

Abstract

The objective of this study is to investigate the potential mutagenic effects of the exposure of mice to aerosols produced from the component liquids of an electronic nicotine delivery system (ENDS). The use of electronic cigarettes (e-cigs) and ENDSs has increased tremendously over the past two decades. From what we know to date, ENDSs contain much lower levels of known carcinogens than tobacco smoke. While conventional tobacco smoke is a well-established mutagen, little is known about the mutagenicity of ENDS aerosols. Here, we report the mutagenic effects of a 3-month whole body exposure of C57 lacI mice (BigBlue TM ) to filtered air (AIR) or ENDS aerosols in several tissues. Aerosols were generated from a 50/50 vegetable glycerin (VG)/propylene glycol (PG) mixture with and without nicotine. The results revealed that in the lung, bladder urothelial tissue, and tongue, mutagenesis was significantly greater in the VG/PG/nicotine group than in the AIR group. In all organs except the bladder, mutagenesis in the VG/PG only group was similar to those exposed to AIR. In the bladder, mutagenesis in the VG/PG group was elevated compared to that in the AIR group. In the liver, mutagenesis was modestly elevated in the VG/PG/nicotine group, but the elevation failed to reach statistical significance. Overall, there were no consistent differences in mutagenesis between the sexes. The results of this study suggest that exposure to e-cig aerosols containing nicotine represents a risk factor for carcinogenesis in several organ systems, and exposure to VG/PG alone may be a risk factor for bladder cancer.

Suggested Citation

  • Dweet Chhaya & Merna Gress & Amna Raja & Wieslawa Kosinska & Terry Gordon & Judith Zelikoff & Joseph B. Guttenplan, 2024. "Effects of E-Cigarette (e-cig) Aerosols on Mutagenesis in Selected Organs in a C57 lacI (BigBlue TM ) Mouse Model," IJERPH, MDPI, vol. 21(12), pages 1-9, December.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:12:p:1693-:d:1547427
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    References listed on IDEAS

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    1. Stephen L. Hamann & Nipapun Kungskulniti & Naowarut Charoenca & Vijj Kasemsup & Suwanna Ruangkanchanasetr & Passara Jongkhajornpong, 2023. "Electronic Cigarette Harms: Aggregate Evidence Shows Damage to Biological Systems," IJERPH, MDPI, vol. 20(19), pages 1-19, September.
    2. Delvon T. Mattingly & Luis Zavala-Arciniega & Jana L. Hirschtick & Rafael Meza & David T. Levy & Nancy L. Fleischer, 2021. "Trends in Exclusive, Dual and Polytobacco Use among U.S. Adults, 2014–2019: Results from Two Nationally Representative Surveys," IJERPH, MDPI, vol. 18(24), pages 1-12, December.
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