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Adaptogens on Depression-Related Outcomes: A Systematic Integrative Review and Rationale of Synergism with Physical Activity

Author

Listed:
  • Isabel A. Sánchez

    (Grupo de Investigación Ciencias Aplicadas al Ejercicio, Deporte y Salud—GICAEDS, Universidad Santo Tomás, Bogotá 205070, Colombia)

  • Jaime A. Cuchimba

    (Grupo de Investigación Ciencias Aplicadas al Ejercicio, Deporte y Salud—GICAEDS, Universidad Santo Tomás, Bogotá 205070, Colombia)

  • María C. Pineda

    (Grupo de Investigación Ciencias Aplicadas al Ejercicio, Deporte y Salud—GICAEDS, Universidad Santo Tomás, Bogotá 205070, Colombia)

  • Yenny P. Argüello

    (Grupo de Investigación Cuerpo, Sujeto y Educación—CSE, Universidad Santo Tomás, Bogotá 205070, Colombia)

  • Jana Kočí

    (Research Division, Dynamical Business & Science Society—DBSS International SAS, Bogotá 110311, Colombia
    Department of Education, Faculty of Education, Charles University, 11636 Prague, Czech Republic)

  • Richard B. Kreider

    (Exercise & Sport Nutrition Laboratory, Human Clinical Research Facility, Texas A&M University, College Station, TX 77843, USA)

  • Jorge L. Petro

    (Research Division, Dynamical Business & Science Society—DBSS International SAS, Bogotá 110311, Colombia
    Research Group in Physical Activity, Sports and Health Sciences (GICAFS), Universidad de Córdoba, Montería 230002, Colombia)

  • Diego A. Bonilla

    (Research Division, Dynamical Business & Science Society—DBSS International SAS, Bogotá 110311, Colombia
    Research Group in Physical Activity, Sports and Health Sciences (GICAFS), Universidad de Córdoba, Montería 230002, Colombia
    Research Group in Biochemistry and Molecular Biology, Universidad Distrital Francisco José de Caldas, Bogotá 110311, Colombia)

Abstract

Depression is considered the most important disorder affecting mental health. The aim of this systematic integrative review was: (i) to describe the effects of supplementation with adaptogens on variables related to depression in adults; and (ii) to discuss the potential combination with physical exercise to aid planning and commissioning future clinical research. An integrative review was developed complementing the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement (PROSPERO registration: CRD42021249682). A total of 41 articles met the inclusion criteria. With a Price index of 46.4%, we found that: (i) Hypericum perforatum (St. John’s Wort) is the most studied and supported adaptogen (17/41 [41.46%], three systematic reviews with meta-analysis) followed by Crocus sativus L. or saffron (6/41 [14.63%], three systematic reviews with meta-analysis and two systematic reviews); (ii) it is possible that the significantly better performance of adaptogens over placebo is due to the reduction of allostatic load via the action of secondary metabolites on BDNF regulation; and, (iii) the number of studies reporting physical activity levels is limited or null for those that combine an exercise program with the consumption of adaptogens. Aware of the need for a multidisciplinary approach for depression treatment, this systematic integrative review provides an up-to-date view for supporting the use of St. John’s Wort and saffron as non-pharmacological strategies while also help commissioning future research on the efficacy of other adaptogens. It also contributes to the design of future clinical research studies that evaluate the consumption of herbal extracts plus physical exercise, mainly resistance training, as a potentially safe and powerful strategy to treat depression.

Suggested Citation

  • Isabel A. Sánchez & Jaime A. Cuchimba & María C. Pineda & Yenny P. Argüello & Jana Kočí & Richard B. Kreider & Jorge L. Petro & Diego A. Bonilla, 2023. "Adaptogens on Depression-Related Outcomes: A Systematic Integrative Review and Rationale of Synergism with Physical Activity," IJERPH, MDPI, vol. 20(7), pages 1-25, March.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:7:p:5298-:d:1109892
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    References listed on IDEAS

    as
    1. Thi Mai Nguyen & Van Huy Nguyen & Jin Hee Kim, 2021. "Physical Exercise and Health-Related Quality of Life in Office Workers: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(7), pages 1-27, April.
    2. Diego A. Bonilla & Luis A. Cardozo & Jorge M. Vélez-Gutiérrez & Adrián Arévalo-Rodríguez & Salvador Vargas-Molina & Jeffrey R. Stout & Richard B. Kreider & Jorge L. Petro, 2022. "Exercise Selection and Common Injuries in Fitness Centers: A Systematic Integrative Review and Practical Recommendations," IJERPH, MDPI, vol. 19(19), pages 1-31, October.
    3. Michael P Hengartner & Janus C Jakobsen & Anders Sørensen & Martin Plöderl, 2020. "Efficacy of new-generation antidepressants assessed with the Montgomery-Asberg Depression Rating Scale, the gold standard clinician rating scale: A meta-analysis of randomised placebo-controlled trial," PLOS ONE, Public Library of Science, vol. 15(2), pages 1-11, February.
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