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Salivary Adiponectin and Albumin Levels on the Gingival Conditions of Patients Undergoing Bariatric Surgery: A Cohort Study

Author

Listed:
  • Silvia Helena de Carvalho Sales-Peres

    (Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil)

  • Jack Houghton

    (Department of Surgery, Faculty of Medicine of Sao Jose do Rio Preto, São José do Rio Preto 15090-000, Brazil)

  • Gabriela de Figueiredo Meira

    (Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil)

  • Patrícia Garcia de Moura-Grec

    (Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil)

  • Sergio Luis Aparecido Brienze

    (Department of Surgery, Faculty of Medicine of Sao Jose do Rio Preto, São José do Rio Preto 15090-000, Brazil)

  • Belkais Abuuasha Karim

    (Center for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London, London WC2R 2LS, UK)

  • Guy Howard Carpenter

    (Center for Host-Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College London, London WC2R 2LS, UK)

Abstract

This study analyzed the salivary proteomics, adiponectin and albumin, related to weight loss and periodontitis in patients undergoing bariatric surgery. This study included fourteen patients with morbid obesity (body mass index, BMI > 40 kg/m 2 ) who underwent bariatric surgery Roux-en-Y gastric bypass (RYGB) in System Health Public in Brazil. Data on demographic and anthropometric measures were extracted from medical records preoperatively and 6 and 12 months post-surgery. The variables assessed were: probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), and stimulated whole-mouth saliva. In this study, saliva samples were analyzed by electrophoresis and immunoblotting. The ELISA kit was used to measure the MMP8 levels to determine potential markers for obesity. Adiponectin and albumin levels were also evaluated. Weight loss was associated with significant changes in patients’ periodontal clinical data. Although 7 out of 10 periodontal patients showed an increase in salivary adiponectin levels after root planning treatment, when analyzed by Western blotting, the increase was not statistically significant (21.1 ± 4.8 to 26.3 ± 9.4 arbitrary units, p > 0.99). There was no correlation between albumin levels and salivary adiponectin pre-surgery, nor 6 months or 12 months after surgery. Weight loss was not improved by low-grade inflammation in bariatric patients, since albumin levels were similar between periods. Periodontitis is an inflammatory disease that is modulated by several factors, among which adiponectin plays an important role for the treatment of periodontal disease.

Suggested Citation

  • Silvia Helena de Carvalho Sales-Peres & Jack Houghton & Gabriela de Figueiredo Meira & Patrícia Garcia de Moura-Grec & Sergio Luis Aparecido Brienze & Belkais Abuuasha Karim & Guy Howard Carpenter, 2023. "Salivary Adiponectin and Albumin Levels on the Gingival Conditions of Patients Undergoing Bariatric Surgery: A Cohort Study," IJERPH, MDPI, vol. 20(7), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:7:p:5261-:d:1106925
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    References listed on IDEAS

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    1. Ghadah Abu-Shawish & Joseph Betsy & Sukumaran Anil, 2022. "Is Obesity a Risk Factor for Periodontal Disease in Adults? A Systematic Review," IJERPH, MDPI, vol. 19(19), pages 1-20, October.
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    Cited by:

    1. Ana Carolina da Silva Pinto & Gabriela de Figueiredo Meira & Francisco Carlos Groppo & Fernanda Ruffo Ortiz & Gerson Foratori & Eduardo Bernabé & Silvia Helena de Carvalho Sales-Peres, 2024. "Impact of Pregestational Obesity on the Oral Health-Related Quality of Life in Brazilian Pregnant Women: A Cohort Study," IJERPH, MDPI, vol. 21(6), pages 1-9, June.

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