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Inherited Epigenetic Hallmarks of Childhood Obesity Derived from Prenatal Exposure to Obesogens

Author

Listed:
  • María Á. Núñez-Sánchez

    (Obesity and Metabolism Research Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain)

  • Almudena Jiménez-Méndez

    (Department of Obstetrics and Gynecology, ‘Virgen de la Arrixaca’ University Clinical Hospital, 30120 Murcia, Spain)

  • María Suárez-Cortés

    (Department of Nursing, Faculty of Nursing, University of Murcia, El Palmar, 30120 Murcia, Spain)

  • María A. Martínez-Sánchez

    (Obesity and Metabolism Research Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain)

  • Manuel Sánchez-Solís

    (Group of Pediatric Research, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain
    Respiratory and Allergy Units, Arrixaca Children’s University Hospital, University of Murcia, 30120 Murcia, Spain)

  • José E. Blanco-Carnero

    (Department of Obstetrics and Gynecology, ‘Virgen de la Arrixaca’ University Clinical Hospital, 30120 Murcia, Spain
    Gynecology, Reproduction and Maternal-Fetal Medicine Research Group, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain)

  • Antonio J. Ruiz-Alcaraz

    (Department of Biochemistry, Molecular Biology B and Immunology, School of Medicine, University of Murcia, Regional Campus of International Excellence “Campus Mare Nostrum”, 30100 Murcia, Spain)

  • Bruno Ramos-Molina

    (Obesity and Metabolism Research Laboratory, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain)

Abstract

Childhood obesity has reached epidemic levels in developed countries and is becoming a major cause for concern in the developing world. The causes of childhood obesity are complex and multifactorial, involving the interaction between individual genetics and environmental and developmental factors. Among the environmental factors, there is a growing interest in understanding the possible relationship between the so-called environmental obesogens and the development of obesity in children. Exposure to these obesogens such as phthalates, bisphenol A, or parabens, has been identified as a promoter of obesity through different mechanisms such as the alteration of adipocyte development from mesenchymal progenitors, the interference with hormone receptors, and induced inflammation. However, less attention has been paid to the inheritance of epigenetic modifications due to maternal exposure to these compounds during pregnancy. Thus, the aim of this review is to summarize the current knowledge of epigenetic modifications due to maternal exposure to those obesogens during pregnancy as well as their potential implication on long-term obesity development in the offspring and transgenerational inheritance of epiphenotypes.

Suggested Citation

  • María Á. Núñez-Sánchez & Almudena Jiménez-Méndez & María Suárez-Cortés & María A. Martínez-Sánchez & Manuel Sánchez-Solís & José E. Blanco-Carnero & Antonio J. Ruiz-Alcaraz & Bruno Ramos-Molina, 2023. "Inherited Epigenetic Hallmarks of Childhood Obesity Derived from Prenatal Exposure to Obesogens," IJERPH, MDPI, vol. 20(6), pages 1-15, March.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:6:p:4711-:d:1090200
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    References listed on IDEAS

    as
    1. Xinyun Xu & Haoying Wu & Paul D. Terry & Ling Zhao & Jiangang Chen, 2022. "Impact of Paraben Exposure on Adiposity-Related Measures: An Updated Literature Review of Population-Based Studies," IJERPH, MDPI, vol. 19(23), pages 1-16, December.
    2. Kimberly Berger & Carly Hyland & Jennifer L. Ames & Ana M. Mora & Karen Huen & Brenda Eskenazi & Nina Holland & Kim G. Harley, 2021. "Prenatal Exposure to Mixtures of Phthalates, Parabens, and Other Phenols and Obesity in Five-Year-Olds in the CHAMACOS Cohort," IJERPH, MDPI, vol. 18(4), pages 1-18, February.
    3. Elsi Haverinen & Mariana F. Fernandez & Vicente Mustieles & Hanna Tolonen, 2021. "Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects," IJERPH, MDPI, vol. 18(24), pages 1-19, December.
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    Cited by:

    1. Anna M. Lavezzi & Bruno Ramos-Molina, 2023. "Environmental Exposure Science and Human Health," IJERPH, MDPI, vol. 20(10), pages 1-6, May.

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