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Exercise-Induced Elevated BDNF Concentration Seems to Prevent Cognitive Impairment after Acute Exposure to Moderate Normobaric Hypoxia among Young Men

Author

Listed:
  • Maciej Chroboczek

    (Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland)

  • Sylwester Kujach

    (Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland)

  • Marcin Łuszczyk

    (Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland)

  • Hideaki Soya

    (Sports Neuroscience Division, Advanced Research Initiative for Human High Performance, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8574, Japan)

  • Radosław Laskowski

    (Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
    Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Sports Neuroscience, Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sports Sciences, University of Tsukuba, Tsukuba 305-8574, Japan)

Abstract

Memory impairment, reduced learning ability, decreased concentration, and psychomotor performance can be all signs of deleterious impact of hypoxia on cognitive functioning. In turn, physical exercise can improve performance and enhance cognitive functions. The purpose of this study was to investigate whether the potential positive effects of exercise performed under normobaric hypoxia can counteract the negative effects of hypoxia on cognitive function, and whether these changes correlate with brain-derived neurotrophic factor (BDNF) concentrations. Seventeen healthy subjects participated in a crossover study where they performed two sessions of single breathing bouts combined with moderate intensity exercise under two conditions: normoxia (NOR EX) and normobaric hypoxia (NH EX). To assess cognitive function, Stroop test was applied. There were no significant differences in any part of the Stroop interference test regardless of the conditions (NOR, NH), despite a statistical decrease in SpO 2 ( p < 0.0001) under normobaric hypoxic conditions. In addition, a statistical increase ( p < 0.0001) in BDNF concentration was observed after both conditions. Acute exercise under normobaric hypoxia did not impair cognitive function despite a significant decrease in SpO 2 . Exercise in such conditions may offset the negative effects of hypoxia alone on cognitive function. This may be related to the significant increase in BDNF concentration and, as a consequence, positively affect the executive functions.

Suggested Citation

  • Maciej Chroboczek & Sylwester Kujach & Marcin Łuszczyk & Hideaki Soya & Radosław Laskowski, 2023. "Exercise-Induced Elevated BDNF Concentration Seems to Prevent Cognitive Impairment after Acute Exposure to Moderate Normobaric Hypoxia among Young Men," IJERPH, MDPI, vol. 20(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3629-:d:1072700
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    References listed on IDEAS

    as
    1. On-Kei Lei & Zhaowei Kong & Paul D. Loprinzi & Qingde Shi & Shengyan Sun & Liye Zou & Yang Hu & Jinlei Nie, 2019. "Severe Hypoxia Does Not Offset the Benefits of Exercise on Cognitive Function in Sedentary Young Women," IJERPH, MDPI, vol. 16(6), pages 1-11, March.
    2. Maciej Chroboczek & Sylwester Kujach & Marcin Łuszczyk & Tomasz Grzywacz & Hideaki Soya & Radosław Laskowski, 2022. "Acute Normobaric Hypoxia Lowers Executive Functions among Young Men despite Increase of BDNF Concentration," IJERPH, MDPI, vol. 19(17), pages 1-10, August.
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