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Acute Normobaric Hypoxia Lowers Executive Functions among Young Men despite Increase of BDNF Concentration

Author

Listed:
  • Maciej Chroboczek

    (Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland)

  • Sylwester Kujach

    (Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland)

  • Marcin Łuszczyk

    (Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland)

  • Tomasz Grzywacz

    (Department of Sport, Institute of Physical Education, Kazimierz Wielki University, 85-064 Bydgoszcz, Poland)

  • Hideaki Soya

    (Sports Neuroscience Division, Advanced Research Initiative for Human High Performance, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8574, Japan)

  • Radosław Laskowski

    (Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
    Laboratory of Exercise Biochemistry and Neuroendocrinology, Department of Sports Neuroscience, Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sports Sciences, University of Tsukuba, Ibaraki 305-8577, Japan)

Abstract

Background: Decreased SpO 2 during hypoxia can cause cognitive function impairment, and the effects of acute hypoxia on high-order brain functions such as executive processing remain unclear. This study’s goal was to examine the impact of an acute normobaric hypoxia breathing session on executive function and biological markers. Methods: Thirty-two healthy subjects participated in a blind study performing two sessions of single 30 min breathing bouts under two conditions (normoxia (NOR) and normobaric hypoxia (NH), FIO 2 = 0.135). The Stroop test was applied to assess cognitive function. Results: No significant difference was observed in the Stroop interference in the “reading” part of the test in either condition; however, there was a significant increase in the “naming” part under NH conditions ( p = 0.003), which corresponded to a significant decrease in SpO 2 ( p < 0.001). There was a significant increase ( p < 0.013) in the brain-derived neurotrophic factor (BDNF) level after NH conditions compared to the baseline, which was not seen in NOR. In addition, a significant drop ( p < 0.001) in cortisol levels in the NOR group and a slight elevation in the NH group was noticed. Conclusions: According to these findings, acute hypoxia delayed cognitive processing for motor execution and reduced the neural activity in motor executive and inhibitory processing. We also noted that this negative effect was associated with decreased SpO 2 irrespective of a rise in BDNF.

Suggested Citation

  • Maciej Chroboczek & Sylwester Kujach & Marcin Łuszczyk & Tomasz Grzywacz & Hideaki Soya & Radosław Laskowski, 2022. "Acute Normobaric Hypoxia Lowers Executive Functions among Young Men despite Increase of BDNF Concentration," IJERPH, MDPI, vol. 19(17), pages 1-10, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:10802-:d:901839
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    Cited by:

    1. Maciej Chroboczek & Sylwester Kujach & Marcin Łuszczyk & Hideaki Soya & Radosław Laskowski, 2023. "Exercise-Induced Elevated BDNF Concentration Seems to Prevent Cognitive Impairment after Acute Exposure to Moderate Normobaric Hypoxia among Young Men," IJERPH, MDPI, vol. 20(4), pages 1-11, February.

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