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Associations between Anxiety, Depression, Chronic Pain and Oral Health-Related Quality of Life, Happiness, and Polymorphisms in Adolescents’ Genes

Author

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  • Ana Luiza Peres Baldiotti

    (Department of Pediatric Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil)

  • Gabrielle Amaral-Freitas

    (Department of Pediatric Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil)

  • Mariane Carolina Faria Barbosa

    (Department of Pediatric Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil)

  • Paula Rocha Moreira

    (Department of Morphology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil)

  • Renato Assis Machado

    (Department of Oral Diagnosis and Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba 13414-903, SP, Brazil)

  • Ricardo Della Coletta

    (Department of Oral Diagnosis and Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba 13414-903, SP, Brazil)

  • Michelle Nascimento Meger

    (School of Health and Biological Sciences, Universidade Positivo, Curitiba 81290-000, PR, Brazil)

  • Saul Martins Paiva

    (Department of Pediatric Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil)

  • Rafaela Scariot

    (Departament of Oral Surgery and Maxilofacial, Federal University of Paraná, Curitiba 81530-000, PR, Brazil)

  • Fernanda de Morais Ferreira

    (Department of Pediatric Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil)

Abstract

Adolescence is marked by changes and vulnerability to the emergence of psychological problems. This study aimed to investigate associations between anxiety/depression/chronic pain and oral health-related quality of life (OHRQoL)/happiness/polymorphisms in the COMT , HTR2A and FKBP5 genes in Brazilian adolescents. A cross-sectional study was conducted with ninety adolescents 13 to 18 years. Anxiety, depression and chronic pain were evaluated using the RDC/TMD. The Oral Health Impact Profile was used to assess oral OHRQoL. The Subjective Happiness Scale was used to assess happiness. Single-nucleotide polymorphisms in COMT (rs165656, rs174675), HTR2A (rs6313, rs4941573) and FKBP5 (rs1360780, rs3800373) were genotyped using the Taqman ® method. Bivariate and multivariate logistic regression analyses were performed ( p < 0.05). Chronic pain and depression were associated with feelings of happiness ( p < 0.05). A significant inverse association was found between anxiety and OHRQoL ( p = 0.004). The presence of minor allele C of COMT rs174675 was significantly associated with depression ( p = 0.040). Brazilian adolescents with depression and chronic pain considers themselves to be less happy than others and those with anxiety are more likely to have a negative impact on OHRQoL. Moreover, the rs174675 variant allele in the COMT gene was associated with depressive symptoms in Brazilian adolescents.

Suggested Citation

  • Ana Luiza Peres Baldiotti & Gabrielle Amaral-Freitas & Mariane Carolina Faria Barbosa & Paula Rocha Moreira & Renato Assis Machado & Ricardo Della Coletta & Michelle Nascimento Meger & Saul Martins Pa, 2023. "Associations between Anxiety, Depression, Chronic Pain and Oral Health-Related Quality of Life, Happiness, and Polymorphisms in Adolescents’ Genes," IJERPH, MDPI, vol. 20(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3321-:d:1067740
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    References listed on IDEAS

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    1. Helliwell, John & Layard, Richard & Sachs, Jeffrey, 2012. "World happiness report," LSE Research Online Documents on Economics 47487, London School of Economics and Political Science, LSE Library.
    2. Mirjam A. G. Sprangers & Jeff A. Sloan & Ruut Veenhoven & Charles S. Cleeland & Michele Y. Halyard, 2009. "The Establishment of the GENEQOL Consortium to Investigate the Genetic Disposition of Patient-Reported Quality-of-Life Outcomes," RatSWD Working Papers 87, German Data Forum (RatSWD).
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