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Damage Effect of Amorphous Carbon Black Nanoparticle Aggregates on Model Phospholipid Membranes: Surface Charge, Exposure Concentration and Time Dependence

Author

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  • Xiao-Feng Wang

    (College of Geography and Environment, Shandong Normal University, Jinan 250358, China)

  • Kun Xu

    (College of Geography and Environment, Shandong Normal University, Jinan 250358, China)

  • Xin-Rui Li

    (College of Geography and Environment, Shandong Normal University, Jinan 250358, China)

  • Ya-Xin Liu

    (College of Geography and Environment, Shandong Normal University, Jinan 250358, China)

  • Jie-Min Cheng

    (College of Geography and Environment, Shandong Normal University, Jinan 250358, China)

Abstract

Commercial nano-scale carbon blacks (CB) are being harnessed widely and may impose potentially hazardous effects because of their unique properties, especially if they have been modified to grow reactive functional groups on their surface. Cytotoxicity of CB has been well studied but the membrane damage mechanisms and role of surface modification are still open to debate. Negatively and positively charged giant unilamellar vesicles (GUVs) were prepared using three lipids as model cell membranes to examine the mechanistic damage of CB and MCB (modified by acidic potassium permanganate) aggregates. Optical images showed that both anionic CB and MCB disrupted the positively charged but not the negatively charged GUVs. This disruption deteriorated with the rise and extension of exposure concentration and time. Lipids extraction caused by CBNs (CB and MCB together are called CBNs) was found. MCB caused more severe disruption than CB. MCB was enveloped into vesicles through an endocytosis-like process at 120 mg/L. MCB mediated the gelation of GUVs, perhaps through C-O-P bonding bridges. The lower hydrodynamic diameter and more negative charges may have been responsible for the distinction effect of MCB over CB. The adhesion and bonding of CBNs to the membrane were favored by electrostatic interaction and the practical application of CBNs warrants more attention.

Suggested Citation

  • Xiao-Feng Wang & Kun Xu & Xin-Rui Li & Ya-Xin Liu & Jie-Min Cheng, 2023. "Damage Effect of Amorphous Carbon Black Nanoparticle Aggregates on Model Phospholipid Membranes: Surface Charge, Exposure Concentration and Time Dependence," IJERPH, MDPI, vol. 20(4), pages 1-12, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:2999-:d:1062398
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    References listed on IDEAS

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    1. Jia Geng & Kyunghoon Kim & Jianfei Zhang & Artur Escalada & Ramya Tunuguntla & Luis R. Comolli & Frances I. Allen & Anna V. Shnyrova & Kang Rae Cho & Dayannara Munoz & Y. Morris Wang & Costas P. Grigo, 2014. "Stochastic transport through carbon nanotubes in lipid bilayers and live cell membranes," Nature, Nature, vol. 514(7524), pages 612-615, October.
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    Cited by:

    1. D. Carrillo-Peña & R. Mateos & A. Morán & A. Escapa, 2024. "Use of Carbon-Based Additives in Bio-Electrochemically Assisted Anaerobic Digestion for Cheese Whey Valorisation," Energies, MDPI, vol. 17(6), pages 1-13, March.

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