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Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors

Author

Listed:
  • Michela Deolmi

    (Pediatric Clinic, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43124 Parma, Italy)

  • Nicola Mattia Decarolis

    (Pediatric Clinic, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43124 Parma, Italy)

  • Matteo Motta

    (Pediatric Clinic, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43124 Parma, Italy)

  • Heidi Makrinioti

    (Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 01451, USA)

  • Valentina Fainardi

    (Pediatric Clinic, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43124 Parma, Italy)

  • Giovanna Pisi

    (Cystic Fibrosis Unit, Pediatric Clinic, Az. Ospedaliera-Universitaria di Parma, Via Gramsci 14, 43124 Parma, Italy)

  • Susanna Esposito

    (Pediatric Clinic, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43124 Parma, Italy)

Abstract

The main risk factor for chronic obstructive pulmonary disease (COPD) is active smoking. However, a considerable amount of people with COPD never smoked, and increasing evidence suggests that adult lung disease can have its origins in prenatal and early life. This article reviews some of the factors that can potentially affect lung development and lung function trajectories throughout the lifespan from genetics and prematurity to respiratory tract infections and childhood asthma. Maternal smoking and air pollution exposure were also analyzed among the environmental factors. The adoption of preventive strategies to avoid these risk factors since the prenatal period may be crucial to prevent, delay the onset or modify the progression of COPD lung disease throughout life.

Suggested Citation

  • Michela Deolmi & Nicola Mattia Decarolis & Matteo Motta & Heidi Makrinioti & Valentina Fainardi & Giovanna Pisi & Susanna Esposito, 2023. "Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors," IJERPH, MDPI, vol. 20(3), pages 1-22, January.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:3:p:2294-:d:1048612
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    References listed on IDEAS

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    1. Vanessa J. Soppa & Roel P. F. Schins & Frauke Hennig & Bryan Hellack & Ulrich Quass & Heinz Kaminski & Thomas A. J. Kuhlbusch & Barbara Hoffmann & Gudrun Weinmayr, 2014. "Respiratory Effects of Fine and Ultrafine Particles from Indoor Sources—A Randomized Sham-Controlled Exposure Study of Healthy Volunteers," IJERPH, MDPI, vol. 11(7), pages 1-19, July.
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    Cited by:

    1. Lyons, Seán & Mao, Likun & Nolan, Anne & O’Sullivan, Vincent, 2023. "The effect of “smoky” coal bans on chronic lung disease among older people in Ireland," Economics & Human Biology, Elsevier, vol. 50(C).

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