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Prenatal Exposure to Metals and Neurodevelopment in Infants at Six Months: Rio Birth Cohort Study of Environmental Exposure and Childhood Development (PIPA Project)

Author

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  • Mônica Seefelder de Assis Araujo

    (Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-592, Brazil)

  • Carmen Ildes Rodrigues Froes-Asmus

    (Postgraduate Program in Perinatal Health, Faculty of Medicine, Maternity School of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro 22240-000, Brazil)

  • Nataly Damasceno de Figueiredo

    (Postgraduate Program in Perinatal Health, Faculty of Medicine, Maternity School of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro 22240-000, Brazil)

  • Volney Magalhães Camara

    (Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-592, Brazil)

  • Ronir Raggio Luiz

    (Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-592, Brazil)

  • Arnaldo Prata-Barbosa

    (Postgraduate Program in Perinatal Health, Faculty of Medicine, Maternity School of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro 22240-000, Brazil
    D’Or Institute for Research & Education (IDOR), Rio de Janeiro 22281-100, Brazil)

  • Marlos Melo Martins

    (School Maternity Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 22240-000, Brazil)

  • Silvana do Couto Jacob

    (Oswaldo Cruz Foundation, National Institute of Quality Control in Health, Rio de Janeiro 21040-900, Brazil)

  • Lisia Maria Gobbo dos Santos

    (Oswaldo Cruz Foundation, National Institute of Quality Control in Health, Rio de Janeiro 21040-900, Brazil)

  • Santos Alves Vicentini Neto

    (Oswaldo Cruz Foundation, National Institute of Quality Control in Health, Rio de Janeiro 21040-900, Brazil)

  • Jorge Fonte de Rezende Filho

    (Postgraduate Program in Perinatal Health, Faculty of Medicine, Maternity School of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro 22240-000, Brazil)

  • Joffre Amim Junior

    (Postgraduate Program in Perinatal Health, Faculty of Medicine, Maternity School of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro 22240-000, Brazil)

Abstract

The PIPA Project is a prospective birth cohort study based in Rio de Janeiro, Brazil, whose pilot study was carried out between October 2017 and August 2018. Arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) concentrations were determined in maternal ( n = 49) and umbilical cord blood ( n = 46). The Denver Developmental Screening Test II (DDST-II) was applied in 50 six-month-old infants. Metals were detected in 100% of the mother and newborn samples above the limits of detection. Maternal blood lead concentrations were higher in premature newborns (GM: 5.72 µg/dL; p = 0.05). One-third of the infants ( n = 17–35.4%) exhibited at least one fail in the neurodevelopment evaluation (fail group). Maternal blood arsenic concentrations were significantly ( p = 0.03) higher in the “fail group” (GM: 11.85 µg/L) compared to infants who did not fail (not fail group) (GM: 8.47 µg/L). Maternal and umbilical cord blood arsenic concentrations were higher in all Denver Test’s domains in the “fail group”, albeit non-statistically significant, showing a tendency for the gross motor domain and maternal blood ( p = 0.07). These findings indicate the need to further investigate the toxic effects of prenatal exposure to metals on infant neurodevelopment.

Suggested Citation

  • Mônica Seefelder de Assis Araujo & Carmen Ildes Rodrigues Froes-Asmus & Nataly Damasceno de Figueiredo & Volney Magalhães Camara & Ronir Raggio Luiz & Arnaldo Prata-Barbosa & Marlos Melo Martins & Sil, 2022. "Prenatal Exposure to Metals and Neurodevelopment in Infants at Six Months: Rio Birth Cohort Study of Environmental Exposure and Childhood Development (PIPA Project)," IJERPH, MDPI, vol. 19(7), pages 1-14, April.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:7:p:4295-:d:786524
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    References listed on IDEAS

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    1. Flavia Ruggieri & Costanza Majorani & Francesco Domanico & Alessandro Alimonti, 2017. "Mercury in Children: Current State on Exposure through Human Biomonitoring Studies," IJERPH, MDPI, vol. 14(5), pages 1-27, May.
    2. Keith Schofield, 2017. "The Metal Neurotoxins: An Important Role in Current Human Neural Epidemics?," IJERPH, MDPI, vol. 14(12), pages 1-23, December.
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