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Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation

Author

Listed:
  • Michal Botek

    (Faculty of Physical Culture, Palacký University Olomouc, 771 11 Olomouc, Czech Republic)

  • Jakub Krejčí

    (Faculty of Physical Culture, Palacký University Olomouc, 771 11 Olomouc, Czech Republic)

  • Michal Valenta

    (Faculty of Physical Culture, Palacký University Olomouc, 771 11 Olomouc, Czech Republic)

  • Andrew McKune

    (Research Institute for Sport and Exercise (UCRISE), University of Canberra, Bruce, ACT 2617, Australia
    Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa)

  • Barbora Sládečková

    (Faculty of Physical Culture, Palacký University Olomouc, 771 11 Olomouc, Czech Republic)

  • Petr Konečný

    (Faculty of Health Sciences, Palacký University Olomouc, 775 15 Olomouc, Czech Republic)

  • Iva Klimešová

    (Faculty of Physical Culture, Palacký University Olomouc, 771 11 Olomouc, Czech Republic)

  • Dalibor Pastucha

    (Clinic of Rehabilitation and Physical Medicine, University Hospital Ostrava, 708 52 Ostrava, Czech Republic)

Abstract

Molecular hydrogen (H 2 ) is potentially a novel therapeutic gas for acute post-coronavirus disease 2019 (COVID-19) patients because it has antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties. The aim of this study was to determine the effect of 14 days of H 2 inhalation on the respiratory and physical fitness status of acute post-COVID-19 patients. This randomized, single-blind, placebo-controlled study included 26 males (44 ± 17 years) and 24 females (38 ± 12 years), who performed a 6-min walking test (6 MWT) and pulmonary function test, specifically forced vital capacity (FVC) and expiratory volume in the first second (FEV1). Symptomatic participants were recruited between 21 and 33 days after a positive polymerase chain reaction test. The experiment consisted of H 2 /placebo inhalation, 2 × 60 min/day for 14 days. Results showed that H 2 therapy, compared with placebo, significantly increased 6 MWT distance by 64 ± 39 m, FVC by 0.19 ± 0.24 L, and, in FEV1, by 0.11 ± 0.28 L (all p ≤ 0.025). In conclusion, H 2 inhalation had beneficial health effects in terms of improved physical and respiratory function in acute post-COVID-19 patients. Therefore, H 2 inhalation may represent a safe, effective approach for accelerating early function restoration in post-COVID-19 patients.

Suggested Citation

  • Michal Botek & Jakub Krejčí & Michal Valenta & Andrew McKune & Barbora Sládečková & Petr Konečný & Iva Klimešová & Dalibor Pastucha, 2022. "Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation," IJERPH, MDPI, vol. 19(4), pages 1-14, February.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:4:p:1992-:d:746408
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    References listed on IDEAS

    as
    1. Marc Spielmanns & Anna-Maria Pekacka-Egli & Sabine Schoendorf & Wolfram Windisch & Matthias Hermann, 2021. "Effects of a Comprehensive Pulmonary Rehabilitation in Severe Post-COVID-19 Patients," IJERPH, MDPI, vol. 18(5), pages 1-13, March.
    2. Lan Yang & Jing Jin & Wenxin Luo & Yuncui Gan & Bojiang Chen & Weimin Li, 2020. "Risk factors for predicting mortality of COVID-19 patients: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-11, November.
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