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Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa

Author

Listed:
  • Marvin E. Langston

    (Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
    Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA)

  • Heidi E. Brown

    (Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA)

  • Charles F. Lynch

    (Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA)

  • Denise J. Roe

    (Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA)

  • Leslie K. Dennis

    (Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA)

Abstract

Intermittent sun exposure is the major environmental risk factor for cutaneous melanoma (CM). Cumulative sun exposure and other environmental agents, such as environmental arsenic exposure, have not shown consistent associations. Ambient ultraviolet radiation (UVR) was used to measure individual total sun exposure as this is thought to be less prone to misclassification and recall bias. Data were analyzed from 1096 CM cases and 1033 controls in the Iowa Study of Skin Cancer and Its Causes, a population-based, case-control study. Self-reported residential histories were linked to satellite-derived ambient UVR, spatially derived environmental soil arsenic concentration, and drinking water arsenic concentrations. In men and women, ambient UVR during childhood and adolescence was not associated with CM but was positively associated during adulthood. Lifetime ambient UVR was positively associated with CM in men (OR for highest vs. lowest quartile: 6.09, 95% confidence interval (CI) 2.21–16.8), but this association was not as strong among women (OR for highest vs. lowest quartile: 2.15, 95% CI 0.84–5.54). No association was detected for environmental soil or drinking water arsenic concentrations and CM. Our findings suggest that lifetime and adulthood sun exposures may be important risk factors for CM.

Suggested Citation

  • Marvin E. Langston & Heidi E. Brown & Charles F. Lynch & Denise J. Roe & Leslie K. Dennis, 2022. "Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa," IJERPH, MDPI, vol. 19(3), pages 1-16, February.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1742-:d:741443
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    References listed on IDEAS

    as
    1. Marvin Langston & Leslie Dennis & Charles Lynch & Denise Roe & Heidi Brown, 2017. "Temporal Trends in Satellite-Derived Erythemal UVB and Implications for Ambient Sun Exposure Assessment," IJERPH, MDPI, vol. 14(2), pages 1-14, February.
    2. Li, W.-Q. & Cho, E. & Weinstock, M.A. & Mashfiq, H. & Qureshi, A.A., 2016. "Epidemiological assessments of skin outcomes in the nurses' health studies," American Journal of Public Health, American Public Health Association, vol. 106(9), pages 1677-1683.
    3. Geoffrey M. Jacquez & Janice Barlow & Robert Rommel & Andy Kaufmann & Michael Rienti & Gillian AvRuskin & Jawaid Rasul, 2013. "Residential Mobility and Breast Cancer in Marin County, California, USA," IJERPH, MDPI, vol. 11(1), pages 1-25, December.
    4. Tze-An Yuan & Yunxia Lu & Karen Edwards & James Jakowatz & Frank L. Meyskens & Feng Liu-Smith, 2019. "Race-, Age-, and Anatomic Site-Specific Gender Differences in Cutaneous Melanoma Suggest Differential Mechanisms of Early- and Late-Onset Melanoma," IJERPH, MDPI, vol. 16(6), pages 1-15, March.
    5. Chantel D Sloan & Rikke B Nordsborg & Geoffrey M Jacquez & Ole Raaschou-Nielsen & Jaymie R Meliker, 2015. "Space-Time Analysis of Testicular Cancer Clusters Using Residential Histories: A Case-Control Study in Denmark," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-12, March.
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