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Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015

Author

Listed:
  • Gabriella M. Anic

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Brian L. Rostron

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Hoda T. Hammad

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Dana M. van Bemmel

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Arseima Y. Del Valle-Pinero

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Carol H. Christensen

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Gladys Erives

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Lisa M. Faulcon

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Benjamin C. Blount

    (Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA)

  • Yuesong Wang

    (Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA)

  • Lanqing Wang

    (Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA)

  • Deepak Bhandari

    (Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA)

  • Antonia M. Calafat

    (Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA)

  • Heather L. Kimmel

    (National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA)

  • Colm D. Everard

    (National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA)

  • Wilson M. Compton

    (National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA)

  • Kathryn C. Edwards

    (Behavioral Health and Health Policy, Westat, Rockville, MD 20850, USA)

  • Maciej L. Goniewicz

    (Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA)

  • Binnian Wei

    (Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA)

  • Andrew Hyland

    (Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA)

  • Dorothy K. Hatsukami

    (Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA)

  • Stephen S. Hecht

    (Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA)

  • Raymond S. Niaura

    (College of Global Public Health, New York University, New York, NY 10003, USA)

  • Nicolette Borek

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Bridget K. Ambrose

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Cindy M. Chang

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

Abstract

Limited data are available for how biomarkers of tobacco exposure (BOE) change when cigarette smokers transition to using electronic nicotine delivery systems (ENDS). Using biomarker data from Waves 1 (2013–2014) and 2 (2014–2015) of the PATH Study, we examined how mean BOE concentrations, including metabolites of nicotine, tobacco-specific nitrosamines (TSNA), polycyclic aromatic hydrocarbons (PAH), and volatile organic compounds (VOC) and metals, changed when 2475 adult smokers transitioned to using ENDS or quit tobacco products. Exclusive smokers who transitioned to dual use had a significant decrease in NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol), but not nicotine metabolites, most PAHs, metals, or VOCs. Exclusive smokers who became dual users had significant reductions in total nicotine equivalents, NNAL, and 2CyEMA (acrylonitrile metabolite), but only in those who reduced cigarettes per day (CPD) by >=50%. Smokers who transitioned to exclusive ENDS use had significant reductions in most TSNAs, PAHs, and VOCs; however, nicotine metabolites did not decrease in dual users who became exclusive ENDS users. Smokers who quit tobacco use had significant decreases in nicotine metabolites, all TSNAs, most PAHs, and most VOCs. Cigarette smokers who became dual users did not experience significant reductions in most BOEs. Reductions were impacted by changes in CPD. However, transitioning from smoking to no tobacco or exclusive ENDS use was associated with reduced exposure to most BOEs measured. Future analyses could incorporate additional waves of PATH data and examine changes in biomarker exposure by ENDS device type and CPD.

Suggested Citation

  • Gabriella M. Anic & Brian L. Rostron & Hoda T. Hammad & Dana M. van Bemmel & Arseima Y. Del Valle-Pinero & Carol H. Christensen & Gladys Erives & Lisa M. Faulcon & Benjamin C. Blount & Yuesong Wang & , 2022. "Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015," IJERPH, MDPI, vol. 19(3), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1462-:d:736340
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    References listed on IDEAS

    as
    1. Víctor R. De Jesús & Deepak Bhandari & Luyu Zhang & Christopher Reese & Kimberly Capella & Denise Tevis & Wanzhe Zhu & Arseima Y. Del Valle-Pinero & Guy Lagaud & Joanne T. Chang & Dana van Bemmel & He, 2020. "Urinary Biomarkers of Exposure to Volatile Organic Compounds from the Population Assessment of Tobacco and Health Study Wave 1 (2013–2014)," IJERPH, MDPI, vol. 17(15), pages 1-12, July.
    Full references (including those not matched with items on IDEAS)

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