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Urinary Biomarkers of Exposure to Volatile Organic Compounds from the Population Assessment of Tobacco and Health Study Wave 1 (2013–2014)

Author

Listed:
  • Víctor R. De Jesús

    (Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA)

  • Deepak Bhandari

    (Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA)

  • Luyu Zhang

    (Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA)

  • Christopher Reese

    (Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA)

  • Kimberly Capella

    (Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA)

  • Denise Tevis

    (Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA)

  • Wanzhe Zhu

    (Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA)

  • Arseima Y. Del Valle-Pinero

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Guy Lagaud

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Joanne T. Chang

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Dana van Bemmel

    (Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA)

  • Heather L. Kimmel

    (National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA)

  • Eva Sharma

    (Westat, 1600 Research Boulevard, Rockville, MD 20850, USA)

  • Maciej L. Goniewicz

    (Division of Cancer Prevention and Population Sciences, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA)

  • Andrew Hyland

    (Division of Cancer Prevention and Population Sciences, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA)

  • Benjamin C. Blount

    (Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control & Prevention, Atlanta, GA 30341, USA)

Abstract

Volatile organic compounds (VOCs) are ubiquitous in the environment. In the United States (U.S.), tobacco smoke is the major non-occupational source of exposure to many harmful VOCs. Exposure to VOCs can be assessed by measuring their urinary metabolites (VOCMs). The Population Assessment of Tobacco and Health (PATH) Study is a U.S. national longitudinal study of tobacco use in the adult and youth civilian non-institutionalized population. We measured 20 VOCMs in urine specimens from a subsample of adults in Wave 1 (W1) (2013–2014) to characterize VOC exposures among tobacco product users and non-users. We calculated weighted geometric means (GMs) and percentiles of each VOCM for exclusive combustible product users (smokers), exclusive electronic cigarette (e-cigarette) users, exclusive smokeless product users, and tobacco product never users. We produced linear regression models for six VOCMs with sex, age, race, and tobacco user group as predictor variables. Creatinine-ratioed levels of VOCMs from exposure to acrolein, crotonaldehyde, isoprene, acrylonitrile, and 1,3-butadiene were significantly higher in smokers than in never users. Small differences of VOCM levels among exclusive e-cigarette users and smokeless users were observed when compared to never users. Smokers showed higher VOCM concentrations than e-cigarette, smokeless, and never users. Urinary VOC metabolites are useful biomarkers of exposure to harmful VOCs.

Suggested Citation

  • Víctor R. De Jesús & Deepak Bhandari & Luyu Zhang & Christopher Reese & Kimberly Capella & Denise Tevis & Wanzhe Zhu & Arseima Y. Del Valle-Pinero & Guy Lagaud & Joanne T. Chang & Dana van Bemmel & He, 2020. "Urinary Biomarkers of Exposure to Volatile Organic Compounds from the Population Assessment of Tobacco and Health Study Wave 1 (2013–2014)," IJERPH, MDPI, vol. 17(15), pages 1-12, July.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:15:p:5408-:d:390633
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    References listed on IDEAS

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    1. Elizabeth Barksdale Boyle & Susan M. Viet & David J. Wright & Lori S. Merrill & K. Udeni Alwis & Benjamin C. Blount & Mary E. Mortensen & John Moye & Michael Dellarco, 2016. "Assessment of Exposure to VOCs among Pregnant Women in the National Children’s Study," IJERPH, MDPI, vol. 13(4), pages 1-16, March.
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    Cited by:

    1. Ayumi Onoue & Yohei Inaba & Kentaro Machida & Takuya Samukawa & Hiromasa Inoue & Hajime Kurosawa & Hiromitsu Ogata & Naoki Kunugita & Hisamitsu Omori, 2022. "Association between Fathers’ Use of Heated Tobacco Products and Urinary Cotinine Concentrations in Their Spouses and Children," IJERPH, MDPI, vol. 19(10), pages 1-11, May.
    2. Gabriella M. Anic & Brian L. Rostron & Hoda T. Hammad & Dana M. van Bemmel & Arseima Y. Del Valle-Pinero & Carol H. Christensen & Gladys Erives & Lisa M. Faulcon & Benjamin C. Blount & Yuesong Wang & , 2022. "Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013–2015," IJERPH, MDPI, vol. 19(3), pages 1-13, January.

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