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Non-Epithelial Ovarian Cancers: How Much Do We Really Know?

Author

Listed:
  • Alison Cheung

    (Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK)

  • Sidrah Shah

    (Department of Palliative Care, Guy’s and St Thomas’ Hospital, Great Maze Pond, London SE1 9RT, UK)

  • Jack Parker

    (Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK)

  • Pavandeep Soor

    (Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK)

  • Anu Limbu

    (Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK)

  • Matin Sheriff

    (Department of Urology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK)

  • Stergios Boussios

    (Department of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK
    Faculty of Life Sciences & Medicine, School of Cancer & Pharmaceutical Sciences, King’s College London, London SE1 9RT, UK
    AELIA Organization, 9th Km Thessaloniki-Thermi, 57001 Thessaloniki, Greece)

Abstract

Non-epithelial ovarian cancers (NEOC) are a group of uncommon malignancies that mainly includes germ cell tumours (GCT), sex cord-stromal tumours (SCST), and some extremely rare tumours, such as small cell carcinomas and sarcomas. Each of these classifications encompasses multiple histologic subtypes. The aetiology and molecular origins of each sub-group of NEOC require further investigation, and our understanding on the genetic changes should be optimised. In this article, we provide an update on the clinical presentation, pathology, genetics, treatment and survival of the main histological subtypes of the GCT and the SCST, as well as of ovarian small cell carcinomas. We also discuss miRNA expression profiles of NEOC and report the currently active clinical trials that include NEOC.

Suggested Citation

  • Alison Cheung & Sidrah Shah & Jack Parker & Pavandeep Soor & Anu Limbu & Matin Sheriff & Stergios Boussios, 2022. "Non-Epithelial Ovarian Cancers: How Much Do We Really Know?," IJERPH, MDPI, vol. 19(3), pages 1-18, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1106-:d:728471
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    Citations

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    Cited by:

    1. Iqra Saani & Nitish Raj & Raja Sood & Shahbaz Ansari & Haider Abbas Mandviwala & Elisabet Sanchez & Stergios Boussios, 2023. "Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours," IJERPH, MDPI, vol. 20(12), pages 1-16, June.
    2. Aruni Ghose & Anita Bolina & Ishika Mahajan & Syed Ahmer Raza & Miranda Clarke & Abhinanda Pal & Elisabet Sanchez & Kathrine Sofia Rallis & Stergios Boussios, 2022. "Hereditary Ovarian Cancer: Towards a Cost-Effective Prevention Strategy," IJERPH, MDPI, vol. 19(19), pages 1-18, September.
    3. Sidrah Shah & Alison Cheung & Mikolaj Kutka & Matin Sheriff & Stergios Boussios, 2022. "Epithelial Ovarian Cancer: Providing Evidence of Predisposition Genes," IJERPH, MDPI, vol. 19(13), pages 1-14, July.

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