IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i3p1085-d728188.html
   My bibliography  Save this article

Predictors of Viral Non-Suppression among Patients Living with HIV under Dolutegravir in Bunia, Democratic Republic of Congo: A Prospective Cohort Study

Author

Listed:
  • Roger T. Buju

    (Department of Public Health, Faculté de Medicine, University of Bunia, Bunia P.O. Box 292, Congo)

  • Pierre Z. Akilimali

    (Department of Biostatistics and Epidemiology, Kinshasa School of Public Health, University of Kinshasa, Kinshasa P.O. Box 11850, Congo)

  • Erick N. Kamangu

    (Département des Sciences de Base, School of Medicine, University of Kinshasa, Kinshasa P.O. Box 11850, Congo)

  • Gauthier K. Mesia

    (Département de Pharmacologie Clinique, School of Medicine, University of Kinshasa, Kinshasa P.O. Box 11850, Congo)

  • Jean Marie N. Kayembe

    (Department Internal Medicine, School of Medicine, University of Kinshasa, Kinshasa P.O. Box 11850, Congo)

  • Hippolyte N. Situakibanza

    (Department of Tropical Medicine and Infectious Disease, School of Medicine, University of Kinshasa, Kinshasa P.O. Box 11850, Congo)

Abstract

The Democratic Republic of the Congo adopted the integrase inhibitor dolutegravir (DTG) as part of its preferred first-line HIV treatment regimen in 2019. This study aimed to identify predictors of viral non-suppression among HIV-infected patients under a DTG-based regimen in the context of ongoing armed conflict since 2017 in the city of Bunia in the DRC. We conducted a cohort study of 468 patients living with HIV under DTG in all health facilities in Bunia. We calculated the proportion of participants with an HIV RNA of below 50 copies per milliliter. About three in four patients (72.8%) in this cohort had a viral load (VL) of <50 copies/mL after 6–12 months. After controlling for the effect of other covariates, the likelihood of having non-suppression remained significantly lower among the 25–34 age group and self-reported naïve patients with a baseline VL of ≥50 copies/mL. The likelihood of having non-suppression remained significantly higher among those who were at advanced stages of the disease, those with abnormal serum creatinine, those with high baseline HIV viremia over 1000 copies/mL, and the Sudanese ethnic group compared to the reference groups. This study suggests that we should better evaluate adherence, especially among adolescents and economically vulnerable populations, such as the Sudanese ethnic group in the city of Bunia. This suggests that an awareness of the potential effects of DTG and tenofovir is important for providers who take care of HIV-positive patients using antiretroviral therapy (ART), especially those with abnormal serum creatinine levels before starting treatment.

Suggested Citation

  • Roger T. Buju & Pierre Z. Akilimali & Erick N. Kamangu & Gauthier K. Mesia & Jean Marie N. Kayembe & Hippolyte N. Situakibanza, 2022. "Predictors of Viral Non-Suppression among Patients Living with HIV under Dolutegravir in Bunia, Democratic Republic of Congo: A Prospective Cohort Study," IJERPH, MDPI, vol. 19(3), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1085-:d:728188
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/3/1085/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/3/1085/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Pierre Zalagile Akilimali & Patou Masika Musumari & Espérance Kashala-Abotnes & Patrick Kalambayi Kayembe & François B Lepira & Paulin Beya Mutombo & Thorkild Tylleskar & Mapatano Mala Ali, 2017. "Disclosure of HIV status and its impact on the loss in the follow-up of HIV-infected patients on potent anti-retroviral therapy programs in a (post-) conflict setting: A retrospective cohort study fro," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-13, February.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Roger T. Buju & Pierre Z. Akilimali & Nguyen-Toan Tran & Erick N. Kamangu & Gauthier K. Mesia & Jean Marie N. Kayembe & Hippolyte N. Situakibanza, 2022. "Determinants of Survival of HIV Patients Receiving Dolutegravir: A Prospective Cohort Study in Conflict-Affected Bunia, Democratic Republic of Congo," IJERPH, MDPI, vol. 19(16), pages 1-10, August.
    2. Roger T. Buju & Pierre Z. Akilimali & Erick N. Kamangu & Gauthier K. Mesia & Jean Marie N. Kayembe & Hippolyte N. Situakibanza, 2022. "Incidence and Predictors of Loss to Follow Up among Patients Living with HIV under Dolutegravir in Bunia, Democratic Republic of Congo: A Prospective Cohort Study," IJERPH, MDPI, vol. 19(8), pages 1-9, April.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Izudi, Jonathan & Cattamanchi, Adithya & Castelnuovo, Barbara & King, Rachel, 2024. "Barriers and facilitators to viral load suppression among people living with HIV following intensive adherence counseling in Kampala, Uganda: A qualitative study," Social Science & Medicine, Elsevier, vol. 343(C).
    2. Roger T. Buju & Pierre Z. Akilimali & Erick N. Kamangu & Gauthier K. Mesia & Jean Marie N. Kayembe & Hippolyte N. Situakibanza, 2022. "Incidence and Predictors of Loss to Follow Up among Patients Living with HIV under Dolutegravir in Bunia, Democratic Republic of Congo: A Prospective Cohort Study," IJERPH, MDPI, vol. 19(8), pages 1-9, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1085-:d:728188. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.