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Fat-Free Mass and Skeletal Muscle Mass Gain Are Associated with Diabetes Remission after Laparoscopic Sleeve Gastrectomy in Males but Not in Females

Author

Listed:
  • Ngan Thi Kim Nguyen

    (International Master Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11301, Taiwan
    School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11301, Taiwan)

  • Nguyen-Phong Vo

    (International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11301, Taiwan)

  • Shih-Yi Huang

    (School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11301, Taiwan
    Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 11301, Taiwan
    Nutrition Research Center, Taipei Medical University Hospital, Taipei 110301, Taiwan)

  • Weu Wang

    (Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 11301, Taiwan
    Division of Digestive Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei 11301, Taiwan
    Department of Surgery, College of Medicine, Taipei Medical University, Taipei 11301, Taiwan)

Abstract

Besides massive body weight loss, laparoscopic sleeve gastrectomy (LSG) causes massive lean mass, including fat-free mass (FFM) and skeletal muscle mass (SM) that present higher metabolic rates in males. This study examines sex differences in FFM and SM changes of type 2 diabetes (T2D) remission at 12 months post-LSG. This cohort study recruited 119 patients (53.7% females) with T2D and obesity (body mass index 42.2 ± 7.0 kg/m 2 ) who underwent LSG. Fat-mass (FM) loss was higher in males than in females (−12.8 ± 6.2% vs. −9.9 ± 5.0%, p = 0.02) after one-year post-operation. Regardless of the weight-loss difference, males had higher FFM and SM gain than did females (12.8 ± 8.0 vs. 9.9 ± 5.0% p = 0.02 and 6.5 ± 4.3% vs. 4.9 ± 6.2%, p = 0.03, respectively). Positive correlations of triglyceride reduction with FM loss (r = 0.47, p = 0.01) and SM gain (r = 0.44, p = 0.02) over 12 months post-operation were observed in males who achieved T2D remission. The T2D remission rate significantly increased 16% and 26% for each additional percentage of FFM and SM gain one year after LSG, which only happened in males. Increased FFM and SM were remarkably associated with T2D remission in males, but evidence lacks for females.

Suggested Citation

  • Ngan Thi Kim Nguyen & Nguyen-Phong Vo & Shih-Yi Huang & Weu Wang, 2022. "Fat-Free Mass and Skeletal Muscle Mass Gain Are Associated with Diabetes Remission after Laparoscopic Sleeve Gastrectomy in Males but Not in Females," IJERPH, MDPI, vol. 19(2), pages 1-11, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:978-:d:725817
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    References listed on IDEAS

    as
    1. Seung-Nam Kim & Jaehee Kim, 2019. "Higher Appendicular Skeletal Muscle Mass Protects Metabolically Healthy Obese Boys but Not Girls from Cardiometabolic Abnormality," IJERPH, MDPI, vol. 16(4), pages 1-7, February.
    2. Mauro Lombardo & Arianna Franchi & Roberto Biolcati Rinaldi & Gianluca Rizzo & Monica D’Adamo & Valeria Guglielmi & Alfonso Bellia & Elvira Padua & Massimiliano Caprio & Paolo Sbraccia, 2021. "Long-Term Iron and Vitamin B12 Deficiency Are Present after Bariatric Surgery, despite the Widespread Use of Supplements," IJERPH, MDPI, vol. 18(9), pages 1-9, April.
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