IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i2p1001-d726345.html
   My bibliography  Save this article

Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study

Author

Listed:
  • Jolanta Zalejska-Fiolka

    (Department of Biochemistry, Faculty of Medical Science in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland)

  • Anna Birková

    (Department of Clinical and Medical Biochemistry, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia)

  • Tomasz Wielkoszyński

    (Higher School of Strategic Planning, 41-303 Dąbrowa Górnicza, Poland)

  • Beáta Hubková

    (Department of Clinical and Medical Biochemistry, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia)

  • Beata Szlachta

    (Department of Biochemistry, Faculty of Medical Science in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland)

  • Rafał Fiolka

    (Doctoral School, Faculty of Medical Science in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland)

  • Urszula Błaszczyk

    (Department of Biochemistry, Faculty of Medical Science in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland)

  • Aleksandra Kuzan

    (Department of Medical Biochemistry, Wrocław Medical University, 50-367 Wrocław, Poland)

  • Andrzej Gamian

    (Institute of Immunology and Experimental Therapy, 53-114 Wrocław, Poland)

  • Mária Mareková

    (Department of Clinical and Medical Biochemistry, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia)

  • Michał Toborek

    (Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL 33136, USA)

Abstract

The current study is focused on the influence of hyperglycemia on weight loss in obese premenopausal women. Specifically, the study evaluated the impact of a six-month individualized low-calorie diet combined with moderate exercise on weight reduction and glucose metabolism in obese women with normoglycemia compared to obese women with moderate hyperglycemia. The results indicated that patients with normoglycemia achieved a successful weight loss, which was connected to a decrease in adipose tissue and reflected by diminished content of visceral fat area (VFA) and percent body fat. In contrast, weight reduction in patients with hyperglycemia was connected not only to the loss of VFA but also to undesired decrease in skeletal muscle mass as well as intracellular and total body water. These unfavorable outcomes were observed despite normalization of glucose metabolism reflected by statistically significant lowering glucose, fructosamine, advanced glycation end-products, and HOMA-IR levels. Overall, the obtained results indicate the importance of the measurement of the carbohydrate profile in obese women and the need for an early introduction of weight reduction strategies before the development of hyperglycemia.

Suggested Citation

  • Jolanta Zalejska-Fiolka & Anna Birková & Tomasz Wielkoszyński & Beáta Hubková & Beata Szlachta & Rafał Fiolka & Urszula Błaszczyk & Aleksandra Kuzan & Andrzej Gamian & Mária Mareková & Michał Toborek, 2022. "Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study," IJERPH, MDPI, vol. 19(2), pages 1-15, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:1001-:d:726345
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/2/1001/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/2/1001/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Jolanta Zalejska-Fiolka & Beáta Hubková & Anna Birková & Beáta Veliká & Beata Puchalska & Sławomir Kasperczyk & Urszula Błaszczyk & Rafał Fiolka & Andrzej Bożek & Beata Maksym & Mária Mareková & Ewa B, 2018. "Prognostic Value of the Modified Atherogenic Index of Plasma during Body Mass Reduction in Polish Obese/Overweight People," IJERPH, MDPI, vol. 16(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:1001-:d:726345. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.