IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2018i1p68-d193548.html
   My bibliography  Save this article

Prognostic Value of the Modified Atherogenic Index of Plasma during Body Mass Reduction in Polish Obese/Overweight People

Author

Listed:
  • Jolanta Zalejska-Fiolka

    (Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia, 40-055 Katowice, Poland)

  • Beáta Hubková

    (Department of Clinical and Medical Biochemistry, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia)

  • Anna Birková

    (Department of Clinical and Medical Biochemistry, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia)

  • Beáta Veliká

    (Department of Clinical and Medical Biochemistry, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia)

  • Beata Puchalska

    (Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia, 40-055 Katowice, Poland)

  • Sławomir Kasperczyk

    (Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia, 40-055 Katowice, Poland)

  • Urszula Błaszczyk

    (Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia, 40-055 Katowice, Poland)

  • Rafał Fiolka

    (Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia, 40-055 Katowice, Poland)

  • Andrzej Bożek

    (Clinical Department of Internal Diseases, Dermatology, and Allergology, School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia, 40-055 Katowice, Poland)

  • Beata Maksym

    (Department of Pharmacology, School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia, 40-055 Katowice, Poland)

  • Mária Mareková

    (Department of Clinical and Medical Biochemistry, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia)

  • Ewa Birkner

    (Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze Medical University of Silesia, 40-055 Katowice, Poland)

Abstract

Although weight loss is recommended for obese patients, it remains questionable how much weight loss is optimal. A novel index that accurately determines the risk of cardiovascular diseases (CVDs) in terms of weight loss is needed. The modified Atherogenic Index of Plasma (AIP), presented here is unique in the literature. It is calculated based on data for anti-atherogenic, high-density lipoprotein cholesterol (HDL-C) fractions, instead of the total HDL-C. This study investigates whether weight loss correlates with CVD risk, and whether the modified AIP allows more accurate diagnostics in obese/overweight people. According to the increase or decrease of AIP during weight loss, 52 Polish patients were subdivided into two groups: group I (increased AIP; n = 16) and group II (decreased AIP; n = 36). The patients’ body mass composition and fasting serum lipid parameters (total cholesterol, triglycerides, HDL-C, and LDL-C (low-density lipoprotein cholesterol)), and cholesterol in 21 lipoprotein sub-fractions were determined. Over six months, all patients reduced their body mass by about 10%. There were no significant differences in anthropometric measures between groups. Increases in large and intermediate HDL-C fractions 1 to 6 and decreases in smaller fractions 7 to 10 were observed in group II. In group I, HDL-C fractions 1 and 10 decreased, while cholesterol in other fractions increased. Increases were observed in the antiatherogenic HDL-C of 52% of group II and 4% of group I. As for atherogenic HDL-C, a decrease of 24% was observed in group II and an increase of 9% in group I. In group I, increases of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and large LDL fractions were noticed, and the reverse in group II. The results show that the modified AIP is a more accurate indicator of CVD risk than existing indices, and that uncontrolled weight reduction does not necessarily have a beneficial influence, and may adversely affect the cardiovascular system.

Suggested Citation

  • Jolanta Zalejska-Fiolka & Beáta Hubková & Anna Birková & Beáta Veliká & Beata Puchalska & Sławomir Kasperczyk & Urszula Błaszczyk & Rafał Fiolka & Andrzej Bożek & Beata Maksym & Mária Mareková & Ewa B, 2018. "Prognostic Value of the Modified Atherogenic Index of Plasma during Body Mass Reduction in Polish Obese/Overweight People," IJERPH, MDPI, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:gam:jijerp:v:16:y:2018:i:1:p:68-:d:193548
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/1/68/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/16/1/68/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Jadwiga Hamułka & Dominika Głąbska & Dominika Guzek & Agnieszka Białkowska & Agnieszka Sulich, 2018. "Intake of Saturated Fatty Acids Affects Atherogenic Blood Properties in Young, Caucasian, Overweight Women Even without Influencing Blood Cholesterol," IJERPH, MDPI, vol. 15(11), pages 1-17, November.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jolanta Zalejska-Fiolka & Anna Birková & Tomasz Wielkoszyński & Beáta Hubková & Beata Szlachta & Rafał Fiolka & Urszula Błaszczyk & Aleksandra Kuzan & Andrzej Gamian & Mária Mareková & Michał Toborek, 2022. "Loss of Skeletal Muscle Mass and Intracellular Water as Undesired Outcomes of Weight Reduction in Obese Hyperglycemic Women: A Short-Term Longitudinal Study," IJERPH, MDPI, vol. 19(2), pages 1-15, January.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2018:i:1:p:68-:d:193548. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.