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Association between Perceived Health-Related Quality of Life and Depression with Frailty in the FRASNET Study

Author

Listed:
  • Giulia B. Delli Zotti

    (Clinical and Health Psychology Unit, IRCCS San Raffaele Scientific Institute, School of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy
    These authors contributed equally to this work.)

  • Lorena Citterio

    (Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, School of Nephrology, Vita-Salute San Raffaele University, 20132 Milan, Italy
    These authors contributed equally to this work.)

  • Sara Farinone

    (Clinical and Health Psychology Unit, IRCCS San Raffaele Scientific Institute, School of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy)

  • Maria Pina Concas

    (Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, 34137 Trieste, Italy)

  • Elena Brioni

    (Nephrology Operative Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy)

  • Laura Zagato

    (Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, School of Nephrology, Vita-Salute San Raffaele University, 20132 Milan, Italy)

  • Elisabetta Messaggio

    (Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, School of Nephrology, Vita-Salute San Raffaele University, 20132 Milan, Italy)

  • Sipontina Faienza

    (Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, School of Nephrology, Vita-Salute San Raffaele University, 20132 Milan, Italy)

  • Marco Simonini

    (Nephrology Operative Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy)

  • Alessandra Napoli

    (Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, “Luigi Sacco” University Hospital, Università di Milano, 20122 Milan, Italy)

  • Valentina Di Mattei

    (Clinical and Health Psychology Unit, IRCCS San Raffaele Scientific Institute, School of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy)

  • Patrizia Rovere-Querini

    (Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy)

  • Lucio Sarno

    (Clinical and Health Psychology Unit, IRCCS San Raffaele Scientific Institute, School of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy)

  • Emilio Clementi

    (Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, “Luigi Sacco” University Hospital, Università di Milano, 20122 Milan, Italy
    Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy)

  • Angelo A. Manfredi

    (Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy)

  • Chiara Lanzani

    (Nephrology Operative Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy)

  • Paolo Manunta

    (Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, School of Nephrology, Vita-Salute San Raffaele University, 20132 Milan, Italy
    Nephrology Operative Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy)

Abstract

Frailty is a major challenge facing the aging world. The phenotype of the frail subject is still far from being satisfactorily defined. We report data on mood, cognition, and quality of life (QoL) in relation to anamnestic factors, health, and socio-economic status in the FRASNET geriatric population (1204 subjects in stable health conditions), which is an observational cohort study that includes fairly balanced groups of Italian frail (421, 35%), pre-frail (449, 37.3%) and robust (334, 27.7%) subjects. A conditional inference tree analysis revealed a substantial influence of psychological variables on frailty. The physical indicator of QoL (Short Form Survey-36-Physical Component Summary, SF-36-PCS) was the predominant variable in the full model (threshold at 39.9, p < 0.001): higher frailty was found in subjects with a caregiver and lower SF-36-PCS. Frailty was also associated with the mental indicator of QoL (Short Form Survey-36-Mental Component Summary, SF-36-MCS), depression (Geriatric Depression Scale, GDS-15), leisure activities, and level of education. In support of the prominent role of inflammation in aging and mental illness, the SF-36-PCS score was correlated with the blood concentration of C-X-C motif chemokine ligand 10 (CXCL10) (r Pearson −0.355, p = 0.015), a critical signal in cell senescence and inflammaging, while the rs7567647 variant in FN1 gene encoding a glycoprotein in the extracellular matrix was significantly associated with frailty in a multivariable model ( p = 0.0006). The perception of health-related QoL and subclinical depression contribute to frailty. Their assessment could improve the identification of older patients at increased risk of adverse outcomes.

Suggested Citation

  • Giulia B. Delli Zotti & Lorena Citterio & Sara Farinone & Maria Pina Concas & Elena Brioni & Laura Zagato & Elisabetta Messaggio & Sipontina Faienza & Marco Simonini & Alessandra Napoli & Valentina Di, 2022. "Association between Perceived Health-Related Quality of Life and Depression with Frailty in the FRASNET Study," IJERPH, MDPI, vol. 19(24), pages 1-18, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:24:p:16776-:d:1002900
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    References listed on IDEAS

    as
    1. Magali Dumontet, 2020. "The dynamics of frailty and change in socio-economic conditions: evidence for the 65+ in Europe [Dynamique de la fragilité et changement des conditions socioéconomiques chez les personnes âgées : u," Post-Print hal-03070314, HAL.
    2. repec:hal:journl:hal-02938663 is not listed on IDEAS
    3. Matthew Lohman & Levent Dumenci & Briana Mezuk, 2016. "Depression and Frailty in Late Life: Evidence for a Common Vulnerability," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 71(4), pages 630-640.
    4. Daan Duppen & Deborah Lambotte & Sarah Dury & An-Sofie Smetcoren & Honghui Pan & Liesbeth De Donder & D-SCOPE ConsortiumA- S Smetcoren & S Dury & L De Donder & N De Witte & E Dierckx & D Lambotte & B , 2020. "Social Participation in the Daily Lives of Frail Older Adults: Types of Participation and Influencing Factors," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 75(9), pages 2062-2071.
    5. Priscila Marconcin & Sharon Barak & Gerson Ferrari & Élvio R. Gouveia & Marcelo de Maio Nascimento & Renata Willig & Margarida Varela & Adilson Marques, 2022. "Prevalence of Frailty and Its Association with Depressive Symptoms among European Older Adults from 17 Countries: A 5-Year Longitudinal Study," IJERPH, MDPI, vol. 19(21), pages 1-11, October.
    Full references (including those not matched with items on IDEAS)

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