IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i21p14520-d964118.html
   My bibliography  Save this article

The Association between the Histological Subtypes of Mesothelioma and Asbestos Exposure Characteristics

Author

Listed:
  • Trudie Vorster

    (Faculty of Health Sciences, Department of Biomedical Sciences, University of Johannesburg, Johannesburg 2028, South Africa
    Pathology Division, National Institute for Occupational Health, National Health Laboratory Service, Johannesburg 2000, South Africa)

  • Julian Mthombeni

    (Faculty of Health Sciences, Department of Biomedical Sciences, University of Johannesburg, Johannesburg 2028, South Africa)

  • Jim teWaterNaude

    (Diagnostic Medicine, Cape Town 7708, South Africa)

  • James Ian Phillips

    (Faculty of Health Sciences, Department of Biomedical Sciences, University of Johannesburg, Johannesburg 2028, South Africa
    Pathology Division, National Institute for Occupational Health, National Health Laboratory Service, Johannesburg 2000, South Africa)

Abstract

Asbestos mining operations have left South Africa with a legacy of asbestos contamination and asbestos-related diseases continue to be a problem. The large-scale mining of three types of asbestos presents a unique opportunity to study malignant mesothelioma of the pleura (mesothelioma) in South Africa. This study aimed to describe the demographics of deceased individuals diagnosed with mesothelioma and explore any associations between the histological morphology of mesothelioma and asbestos characteristics. We reviewed the records of all deceased miners and ex-miners from the Pathology Automation System (PATHAUT) database of the National Institute of Occupational Health (NIOH) that were histologically diagnosed with mesothelioma in the period from January 2006–December 2016 (11 years). The study population does not include all cases of mesothelioma in South Africa but rather those that reached the compensation system. Crocidolite asbestos fibres were identified in the majority of mesothelioma cases ( n = 140; 53.4%). The epithelioid subtype was most commonly present in both occupational and environmental cases. Cases with the sarcomatous subtype were older at death and fewer female cases were diagnosed with this subtype. No relationship between mesothelioma subtype and asbestos type or asbestos burden or fibre size was established.

Suggested Citation

  • Trudie Vorster & Julian Mthombeni & Jim teWaterNaude & James Ian Phillips, 2022. "The Association between the Histological Subtypes of Mesothelioma and Asbestos Exposure Characteristics," IJERPH, MDPI, vol. 19(21), pages 1-12, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:14520-:d:964118
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/21/14520/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/21/14520/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Braun, L. & Kisting, S., 2006. "Asbestos-related disease in South Africa: The social production of an invisible epidemic," American Journal of Public Health, American Public Health Association, vol. 96(8), pages 1386-1396.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Gladness Nteboheng Lion & Joshua Oluwole Olowoyo, 2023. "Possible Sources of Trace Metals in Obese Females Living in Informal Settlements near Industrial Sites around Gauteng, South Africa," IJERPH, MDPI, vol. 20(6), pages 1-13, March.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Benjamin Lysaniuk & María Fernanda Cely-García & Margarita Giraldo & Joan M. Larrahondo & Laura Marcela Serrano-Calderón & Juan Carlos Guerrero-Bernal & Leonardo Briceno-Ayala & Esteban Cruz Rodriguez, 2021. "Using GIS to Estimate Population at Risk Because of Residence Proximity to Asbestos Processing Facilities in Colombia," IJERPH, MDPI, vol. 18(24), pages 1-17, December.
    2. Ramos-Toro, Diego, 2017. "Social Cohesion and Carbon Emissions," MPRA Paper 82396, University Library of Munich, Germany.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:14520-:d:964118. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.