IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i21p14500-d963770.html
   My bibliography  Save this article

Expression of Matrix Metalloproteinase-2,-7,-9 in Serum during Pregnancy in Patients with Pre-Eclampsia: A Prospective Study

Author

Listed:
  • Ayibaota Bahabayi

    (Department of Clinical Laboratory, Peking University Third Hospital, Beijing 100191, China
    Department of Clinical Laboratory, Peking University People’s Hospital, Beijing 100033, China
    These authors contributed equally to this work.)

  • Nan Yang

    (Department of Blood Transfusion, Peking University Third Hospital, Beijing 100191, China
    These authors contributed equally to this work.)

  • Tong Xu

    (Department of Clinical Laboratory, Peking University Third Hospital, Beijing 100191, China)

  • Yuting Xue

    (Department of Clinical Laboratory, Peking University Third Hospital, Beijing 100191, China)

  • Lijuan Ma

    (Department of Clinical Laboratory, Peking University Third Hospital, Beijing 100191, China)

  • Xunke Gu

    (Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China)

  • Yongqing Wang

    (Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China)

  • Keke Jia

    (Department of Clinical Laboratory, Peking University Third Hospital, Beijing 100191, China)

Abstract

Background: Matrix Metalloproteinases (MMPs) have been found to have important roles in vascular pathology and may be involved in the occurrence of pre-eclampsia. In this study, the serum levels of MMP-2, -7, -9 in normal pregnant women and pre-eclampsia patients were analyzed to assess their predictive value. Methods: A total of 1563 pregnant women from Peking University Third Hospital, from February 2021 to October 2021, were enrolled. Serum samples were collected from patients one to three times, during the different trimesters. Among the 102 singleton pre-eclampsia patients, we collected samples from 33 patients in the first trimester (6–13 GW), 33 in the second trimester (14–28 GW), 41 in the third trimester (29–41 GW) and 28 after onset of pre-eclampsia. Samples from each trimester were collected before the onset of pre-eclampsia. Then we selected 35, 37, 43 and 25 samples from 124 healthy pregnant women by matching their age, BMI and gestational weeks, using these as the control groups. Serum levels of MMP-2, -7, -9 were detected by ELISA. The receiver operating characteristic (ROC) curve was used to evaluate their predictive value. Results: Except for the first trimester, MMP-2 and MMP-7 were significantly higher in the pre-eclampsia group ( p < 0.5). Additionally, in the pre-eclampsia group, MMP-9 increased significantly in the first trimester and after the onset of pre-eclampsia but decreased significantly in the second and third trimesters ( p < 0.5). The ROC curve indicated that MMP-9, MMP-2 and MMP-7 were the best indicators for predicting pre-eclampsia in the first, second and third trimesters, respectively. Conclusion: Increased MMP-2 and MMP-7 levels and a decreased MMP-9 level seem to be related to the pathogenesis of pre-eclampsia and are expected to be potential predictors of pre-eclampsia.

Suggested Citation

  • Ayibaota Bahabayi & Nan Yang & Tong Xu & Yuting Xue & Lijuan Ma & Xunke Gu & Yongqing Wang & Keke Jia, 2022. "Expression of Matrix Metalloproteinase-2,-7,-9 in Serum during Pregnancy in Patients with Pre-Eclampsia: A Prospective Study," IJERPH, MDPI, vol. 19(21), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:14500-:d:963770
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/21/14500/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/21/14500/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Offer Erez & Roberto Romero & Eli Maymon & Piya Chaemsaithong & Bogdan Done & Percy Pacora & Bogdan Panaitescu & Tinnakorn Chaiworapongsa & Sonia S Hassan & Adi L Tarca, 2017. "The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-28, July.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Antonio Sarría-Santamera & Antonio Simone Laganà & Milan Terzic, 2022. "Women’s Health and Gynecology: Old Challenges and New Insights," IJERPH, MDPI, vol. 19(24), pages 1-6, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Adi L Tarca & Roberto Romero & Neta Benshalom-Tirosh & Nandor Gabor Than & Dereje W Gudicha & Bogdan Done & Percy Pacora & Tinnakorn Chaiworapongsa & Bogdan Panaitescu & Dan Tirosh & Nardhy Gomez-Lope, 2019. "The prediction of early preeclampsia: Results from a longitudinal proteomics study," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-34, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:14500-:d:963770. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.