IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i20p13177-d940974.html
   My bibliography  Save this article

Pre-Conceptional Anti-Thyroid Antibodies and Thyroid Function in Association with Natural Conception Rates

Author

Listed:
  • Shoko Konishi

    (Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan)

  • Yuki Mizuno

    (Department of Human Ecology, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan)

Abstract

Thyroid functioning is an integral part of the endocrine system that supports conception and pregnancy. Frequent consumption of seafood and iodine by Japanese people may adversely affect their thyroid function. Thus, in this study, we aimed to analyze the associations between iodine intake, thyroid hormones, autoimmunity, and natural conception rates in Japanese women trying to conceive their first child. A prospective study of 24 weeks targeted 80 women with no history of infertility, who did not plan to undergo fertility treatment. Concentrations of urinary iodine concentration and thyroid biomarkers in the serum at enrollment were measured. Thirty-five women naturally conceived during the follow-up. The median (inter-quartile range) urinary concentration of iodine was 297 (165, 500) μg/L. Free triiodothyronine (T3) and free thyroxin (T4) negatively correlated with urinary iodine concentrations. Women with anti-thyroid peroxidase (anti-TPO) ≥ 16 IU/mL had lower conception rates (hazard ratio: 0.28, 95% confidence interval, 0.08–0.92) compared with those with anti-TPO < 16 IU/mL, after adjusting for age and coital frequency. None of anti-thyroglobulin antibody, free T3, free T4, or thyroid-stimulating hormone showed significant associations with conception rate after adjusting for age and coital frequency. The negative association between thyroid autoimmunity and natural conception rates warrants further investigation.

Suggested Citation

  • Shoko Konishi & Yuki Mizuno, 2022. "Pre-Conceptional Anti-Thyroid Antibodies and Thyroid Function in Association with Natural Conception Rates," IJERPH, MDPI, vol. 19(20), pages 1-9, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:20:p:13177-:d:940974
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/20/13177/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/20/13177/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Shoko Konishi & Fumiko Kariya & Kisuke Hamasaki & Lena Takayasu & Hisashi Ohtsuki, 2021. "Fecundability and Sterility by Age: Estimates Using Time to Pregnancy Data of Japanese Couples Trying to Conceive Their First Child with and without Fertility Treatment," IJERPH, MDPI, vol. 18(10), pages 1-13, May.
    2. Shoko Konishi & Tomoko T. Saotome & Keiko Shimizu & Mari S. Oba & Kathleen A. O’Connor, 2020. "Coital Frequency and the Probability of Pregnancy in Couples Trying to Conceive Their First Child: A Prospective Cohort Study in Japan," IJERPH, MDPI, vol. 17(14), pages 1-11, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:20:p:13177-:d:940974. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.