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Association of Plasma Cortisol Levels with Gestational Age and Anthropometric Values at Birth in Preterm Infants

Author

Listed:
  • Masako Aoki

    (Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan
    These authors contributed equally to this work.)

  • Tatsuhiko Urakami

    (Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan)

  • Nobuhiko Nagano

    (Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan
    These authors contributed equally to this work.)

  • Ryoji Aoki

    (Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan)

  • Ichiro Morioka

    (Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan)

Abstract

There are no study reports to clarify the association between gestational age (GA) or anthropometric values at birth, and plasma cortisol levels in the blood of preterm infants at birth and at one month of age. This hospital-based retrospective cohort study included infants born at <37 weeks’ gestation between 2019 and 2021. First, the association between plasma cortisol level and GA or anthropometric values at birth (birth weight standard deviation score [SDS], birth length SDS, and birth head circumference SDS) was identified by regression and multiple regression analyses. Second, plasma cortisol levels in the umbilical cord at birth and at one month of age were compared between small-for-gestational age (SGA) and non-SGA infants. Sixty-one preterm infants were enrolled (SGA: 24 and non-SGA: 37). Plasma cortisol levels at birth were significantly associated with GA. Plasma cortisol levels at one month of age were associated with GA and birth head circumference SDS. Plasma cortisol levels at birth were significantly higher in SGA than non-SGA ( p = 0.010). GA was an independent determinant of plasma cortisol levels at birth. SGA infants had a high plasma cortisol level at birth; resulting in speculation that a high plasma cortisol level at birth may predict abnormal neurological outcomes.

Suggested Citation

  • Masako Aoki & Tatsuhiko Urakami & Nobuhiko Nagano & Ryoji Aoki & Ichiro Morioka, 2022. "Association of Plasma Cortisol Levels with Gestational Age and Anthropometric Values at Birth in Preterm Infants," IJERPH, MDPI, vol. 19(18), pages 1-11, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11448-:d:912459
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    References listed on IDEAS

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    1. Aneta Słabuszewska-Jóżwiak & Marta Włodarczyk & Krzysztof Kilian & Zbigniew Rogulski & Michał Ciebiera & Jolanta Szymańska-Majchrzak & Kornelia Zaręba & Jacek Krzysztof Szymański & Dorota Raczkiewicz , 2020. "Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol?," IJERPH, MDPI, vol. 17(15), pages 1-13, August.
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