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Potentially Inappropriate Medication Use in Patients with Dementia

Author

Listed:
  • Kyungwon Yoon

    (Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea
    Department of Pharmacy, Kyung Hee University Hospital, Seoul 02447, Korea
    These authors contributed equally to this work.)

  • Jung-Tae Kim

    (Department of Pharmacy, Kyung Hee University Hospital at Gangdong, Seoul 05278, Korea
    These authors contributed equally to this work.)

  • Won-Gun Kwack

    (Division of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital, Seoul 02447, Korea
    These authors contributed equally to this work.)

  • Donghyun Kim

    (Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea)

  • Kyung-Tae Lee

    (Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea
    Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea)

  • Seungwon Yang

    (Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea
    Department of Regulatory Science, College of Pharmacy, Graduate School, Kyung Hee University, Seoul 02447, Korea)

  • Sangmin Lee

    (Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea
    Department of Regulatory Science, College of Pharmacy, Graduate School, Kyung Hee University, Seoul 02447, Korea)

  • Yeo-Jin Choi

    (Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea
    Department of Regulatory Science, College of Pharmacy, Graduate School, Kyung Hee University, Seoul 02447, Korea)

  • Eun-Kyoung Chung

    (Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea
    Department of Pharmacy, Kyung Hee University Hospital at Gangdong, Seoul 05278, Korea
    Department of Regulatory Science, College of Pharmacy, Graduate School, Kyung Hee University, Seoul 02447, Korea)

Abstract

The objective of this study was to characterize the epidemiology of using potentially inappropriate medications associated with dementia exacerbation (DPIMs) in elderly outpatients with dementia. Electronic medical records were retrospectively reviewed for geriatric patients with dementia who were prescribed at least one medication in 2016 at a tertiary, university-affiliated hospital. The 2015 Beers criteria were used to define DPIMs. Logistic regression was performed to identify factors associated with prescribing DPIMs in patients with dementia. Among 2100 patients included in our study, 987 (47.0%) patients were prescribed at least one DPIM. Benzodiazepines were the most frequently prescribed DPIM followed by anticholinergics, histamine H2-receptor blockers, and zolpidem. The risk of prescribing DPIMs was significantly increased in female patients (odds ratio (OR) 1.355) with polypharmacy (OR 5.146) and multiple comorbidities (OR 1.129) ( p < 0.05 for all). Coexistence of Parkinson’s disease (OR 1.799), mood disorder (OR 1.373), or schizophrenia (OR 4.116) in patients with dementia further increased the likelihood of receiving DPIMs. In conclusion, DPIMs were commonly used in elderly patients with dementia in Korea with benzodiazepines most frequently prescribed followed by anticholinergics. Female patients using polypharmacy with multiple comorbidities should be closely monitored to minimize unnecessary DPIM use and, ultimately, DPIM-related harms.

Suggested Citation

  • Kyungwon Yoon & Jung-Tae Kim & Won-Gun Kwack & Donghyun Kim & Kyung-Tae Lee & Seungwon Yang & Sangmin Lee & Yeo-Jin Choi & Eun-Kyoung Chung, 2022. "Potentially Inappropriate Medication Use in Patients with Dementia," IJERPH, MDPI, vol. 19(18), pages 1-12, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11426-:d:912081
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    References listed on IDEAS

    as
    1. Tzu-Chueh Wang & Pou-Jen Ku & Hai-Lin Lu & Kung-Chuan Hsu & Damien Trezise & Hue-Yu Wang, 2019. "Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly," IJERPH, MDPI, vol. 16(12), pages 1-12, June.
    2. Hae-Young Park & Ji-Won Park & Hong Ji Song & Hyun Soon Sohn & Jin-Won Kwon, 2017. "The Association between Polypharmacy and Dementia: A Nested Case-Control Study Based on a 12-Year Longitudinal Cohort Database in South Korea," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-17, January.
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