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Association between Pulse Pressure and Onset of Dementia in an Elderly Korean Population: A Cohort Study

Author

Listed:
  • Yongku Jung

    (Department of Health Policy and Management, Graduate School of Public Health, Yonsei University, Seoul 03722, Korea
    These authors contributed equally to this work.)

  • Dong-Woo Choi

    (Institute of Health Services Research, Yonsei University, Seoul 03722, Korea
    Department of Public Health, Graduate School, Yonsei University, Seoul 03722, Korea
    These authors contributed equally to this work.)

  • Sohee Park

    (Department of Biostatistics, Yonsei University Graduate School of Public Health, Seoul 03722, Korea)

  • Sung-In Jang

    (Institute of Health Services Research, Yonsei University, Seoul 03722, Korea
    Department of Preventive Medicine, Yonsei University College of Medicine, Seoul 03722, Korea)

  • Eun-Cheol Park

    (Institute of Health Services Research, Yonsei University, Seoul 03722, Korea
    Department of Preventive Medicine, Yonsei University College of Medicine, Seoul 03722, Korea)

Abstract

Objective: There is paucity of studies on the association between pulse pressure and the development of dementia, although this association has already been established. This study aimed at investigating the association between pulse pressure and the onset of dementia. Methods: We used the South Korean National Health Insurance Service claims cohort data to select 149,663 patients without dementia aged ≥60 years. We calculated adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for dementia using Cox proportional hazard models according to a pulse pressure classification (<50, 50–59, 60–69, 70–79, 80–89, or 90+). Results: Compared to women with pulse pressure <50, those with pulse pressures of 50–59, 60–69, and 90+ had higher HRs for dementia (1.14, 1.22, and 1.03, respectively). These associations were particularly strong in those on Medicaid insurance and from rural regions. However, there were no statistically significant results among men. Conclusions: A higher pulse pressure was associated with an elevated risk of dementia in women aged >60 years, particularly those on Medicaid and from rural regions, possibly due to their inability to access hypertension and other medical treatment. The establishment of dementia indicators will help to guide future health policies for the prevention of dementia.

Suggested Citation

  • Yongku Jung & Dong-Woo Choi & Sohee Park & Sung-In Jang & Eun-Cheol Park, 2020. "Association between Pulse Pressure and Onset of Dementia in an Elderly Korean Population: A Cohort Study," IJERPH, MDPI, vol. 17(5), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1657-:d:328177
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    References listed on IDEAS

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    1. Hae-Young Park & Ji-Won Park & Hong Ji Song & Hyun Soon Sohn & Jin-Won Kwon, 2017. "The Association between Polypharmacy and Dementia: A Nested Case-Control Study Based on a 12-Year Longitudinal Cohort Database in South Korea," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-17, January.
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