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Challenges in Predicting the Change in the Cumulative Exposure of New Tobacco and Related Products Based on Emissions and Toxicity Dose–Response Data

Author

Listed:
  • Yvonne C. M. Staal

    (National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands)

  • Wieneke Bil

    (National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands)

  • Bas G. H. Bokkers

    (National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands)

  • Lya G. Soeteman-Hernández

    (National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands)

  • W. Edryd Stephens

    (School of Earth & Environmental Sciences, University of St Andrews, St Andrews KY16 9AJ, UK)

  • Reinskje Talhout

    (National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands)

Abstract

Many novel tobacco products have been developed in recent years. Although many may emit lower levels of several toxicants, their risk in the long term remains unclear. We previously published a method for the exposure assessment of mixtures that can be used to compare the changes in cumulative exposure to carcinogens among tobacco products. While further developing this method by including more carcinogens or to explore its application to non-cancer endpoints, we encountered a lack of data that are required for better-substantiated conclusions regarding differences in exposure between products. In this special communication, we argue the case for more data on adverse health effects, as well as more data on the composition of the emissions from tobacco products. Such information can be used to identify significant changes in relevance to health using the cumulative exposure method with different products and to substantiate regulatory decisions.

Suggested Citation

  • Yvonne C. M. Staal & Wieneke Bil & Bas G. H. Bokkers & Lya G. Soeteman-Hernández & W. Edryd Stephens & Reinskje Talhout, 2022. "Challenges in Predicting the Change in the Cumulative Exposure of New Tobacco and Related Products Based on Emissions and Toxicity Dose–Response Data," IJERPH, MDPI, vol. 19(17), pages 1-15, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:10528-:d:896047
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    References listed on IDEAS

    as
    1. Aleksandra Ratajczak & Piotr Jankowski & Piotr Strus & Wojciech Feleszko, 2020. "Heat Not Burn Tobacco Product—A New Global Trend: Impact of Heat-Not-Burn Tobacco Products on Public Health, a Systematic Review," IJERPH, MDPI, vol. 17(2), pages 1-12, January.
    2. Wout Slob & Lya G. Soeteman‐Hernández & Wieneke Bil & Yvonne C.M. Staal & W. Edryd Stephens & Reinskje Talhout, 2020. "A Method for Comparing the Impact on Carcinogenicity of Tobacco Products: A Case Study on Heated Tobacco Versus Cigarettes," Risk Analysis, John Wiley & Sons, vol. 40(7), pages 1355-1366, July.
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